Results 21 to 30 of about 75,248 (241)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Spatial and temporal distribution characteristics and evolution of traditional villages in the Qihe River Basin of China

Scientific Reports
The Qihe River Basin, renowned as one of the cradles of Chinese civilization and a river that flows in the Psalms, boasts a rich cultural heritage. River basins have historically been the cradle of civilization, nurturing the prosperity and enduring ...
YunXing Zhang, NaNa Han, Baien Zhang, ChenChen Lu, MeiYu Yang, FeiFei Zhai, HaiDong Li   +6 more
doaj   +1 more source

Summarising the seismic risk reduction processes in standard residential buildings of Yerevan: why don't we have real results?

Budownictwo i Architektura
The article addresses issues of ensuring housing safety. The aim of this work is to summarise the tasks set by the state for seismic risk reduction in Yerevan and to identify their reflection in the process of increasing the seismic resistance of ...
Karen Azatyan, Karen Rashidyants, Anush Ohanyan   +2 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Novel Unsupervised Machine Learning Method for Identifying Falling from Height Hazards in Building Information Models through Path Simulation Sampling

Advances in Civil Engineering
Falling from height (FFH) is a significant safety concern in the construction industry. It requires construction safety managers to identify and prevent FFH from occurring as early as possible.
Yu Yan, Shen Zhang, Xingyu Wang, Xuechun Li   +3 more
doaj   +1 more source

Sustainable Co-Habitation Housing Design: A Computational Approach for Addressing Biodiversity Threats in the Galapagos Islands

Architecture
This study explores sustainable housing solutions for urban areas in the Galapagos Islands, aiming to balance human needs with ecosystem preservation by fostering co-habitation between local communities and native species.
Gianfranco Maiorano, Natalia Juca Freire, Rapas Teparaksa, Pinak Dilip Bhapkar, Elif Erdine, Milad Showkatbakhsh   +5 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Research on the optimization design method of solar-wind-hydrogen hybrid energy system based on NSGA-II and entropy-weight TOPSIS framework

Discover Sustainability
The decarbonization and resilience enhancement of building energy systems face critical challenges due to the intermittent nature of solar/wind power and the continuous demand for heat/electricity.
Ying Wang, Xun Dong, Jian Wang
doaj   +1 more source

Generation Mechanisms of the Complex Adaptive System in Traditional Settlements: A Case Study of Zheshui Village, China

Buildings
Traditional villages embody tangible repositories of historical, cultural, and geographical heritage, and their sustainable and authentic development poses a global challenge.
Yunxing Zhang, Baien Zhang, Nana Han, Chenchen Lu, Jie Gao, Haidong Li, Feifei Zhai   +6 more
doaj   +1 more source