Results 31 to 40 of about 9,719,459 (254)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Novel Unsupervised Machine Learning Method for Identifying Falling from Height Hazards in Building Information Models through Path Simulation Sampling

Advances in Civil Engineering
Falling from height (FFH) is a significant safety concern in the construction industry. It requires construction safety managers to identify and prevent FFH from occurring as early as possible.
Yu Yan, Shen Zhang, Xingyu Wang, Xuechun Li   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The changing patterns of architectural design education in the UK [PDF]

, 2008
Digital technologies have been introduced to students of architecture for over two decades and at present it could be argued that students are producing some of the highest quality designs, and some of the most interesting forms ever to come from ...
Horne, Margaret, B. Giddings, Giddings, Bob, M. Horne   +3 more
core  

Structural design and analysis of connected structure in Chengdu Financial Innovation Center Phase 1

Jianzhu Jiegou
The project of Chengdu Financial Innovation Center Phase 1 consists of five high-rise towers，large-chassis podiums and large-span sky-bridge to form an enclosed building cluster. Among them，the T1 tower adopts steel frame structure，the T2～T5 towers adopt
ZHU Jing, LIU Wei, WANG Wu, ZHU Guo, LUO Aolei, SHU Yuan   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Application of direct analysis method in lightweight spatial steel structures

Jianzhu Jiegou
In order to evaluating the applicability and advantages of the direct analysis method for lightweight spatial steel structures，a lightweight spatial steel structure formed by a single-layer diagonal grid was taken as the research object to compare the ...
WANG Pengfei, WANG Wu, FU Anjun, XIE Kai, SONG Fuping, CAI Xunhua   +5 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Architectural design rewriting as an architecture description language [PDF]

, 2008
Architectural Design Rewriting (ADR) is a declarative rule-based approach for the design of dynamic software architectures. The key features that make ADR a suitable and expressive framework are the algebraic presentation of graph-based structures and ...
Lluch-Lafuente, Alberto, Bruni, Roberto, Tuosto, Emilio, Montanari, Ugo   +3 more
core