Results 51 to 60 of about 145,790 (269)

A computational fluid dynamic-based method for analyzing the nonlinear relationship between windage loss and pressure in a geotechnical centrifuge

SN Applied Sciences, 2021
Temperature control is an important limitation to further increase in geotechnical centrifuge power. Although vacuum pumps can reduce windage loss, they also negatively affect heat transfer performance.
Yi-Nan Guo, Yi Yang, Jun-Xiang Yu, De Ding, Ya-Lin Wang   +4 more
doaj   +1 more source

Manufacturing urbanism: an architectural practice for unfinished cities [PDF]

, 2012
This PhD is a reflection upon an architectural practice developed over twelve years, incorporating architectural design, teaching and writing. The practice consists of a variety of projects ranging from full-scale architectural interventions to ...
Gretchen Wilkins
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Technical System Construction for Total Factor Library of Management Manual for Shanghai Planning Implementation Platform [PDF]

E3S Web of Conferences
At present, with the continuous advancement of urban development, an increasing number of regional overall development projects utilize the planning implementation platform to carry out design control and construction throughout the full life cycle of ...
Zhou Ying, Zhang Li
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Architectural students' year-out training experience in architectural offices in the UK [PDF]

, 2015
This paper investigates architectural students’ ‘year-out’ learning experience in practices after completing RIBA Part I study within a UK university. By interviewing and analysing their reflections on the experience, the study examines how individual ...
Orr, Kevin, Gao, Yun
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Case analysis and design logic framework of eco-environment-oriented development (EOD) in China

Journal of Asian Architecture and Building Engineering
As China undergoes a strategic shift from a growth-centric development paradigm to one that prioritizes environmental sustainability, the Eco-Environment-Oriented Development (EOD) model has emerged as a policy innovation and is currently being ...
Lu Li, Le Luo, Yang Qu, Mao Han
doaj   +1 more source