Results 51 to 60 of about 9,719,459 (254)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Sustainable Co-Habitation Housing Design: A Computational Approach for Addressing Biodiversity Threats in the Galapagos Islands

Architecture
This study explores sustainable housing solutions for urban areas in the Galapagos Islands, aiming to balance human needs with ecosystem preservation by fostering co-habitation between local communities and native species.
Gianfranco Maiorano, Natalia Juca Freire, Rapas Teparaksa, Pinak Dilip Bhapkar, Elif Erdine, Milad Showkatbakhsh   +5 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Manufacturing urbanism: an architectural practice for unfinished cities [PDF]

, 2012
This PhD is a reflection upon an architectural practice developed over twelve years, incorporating architectural design, teaching and writing. The practice consists of a variety of projects ranging from full-scale architectural interventions to ...
Gretchen Wilkins
core  

Study on analysis and control measures of cracks in UHPC prefabricated panel

Jianzhu Jiegou
The crack generation（crack distribution and width）of ultra-high performance concrete（UHPC）prefabricated panel and ordinary concrete panel in the production，transportation and use stages were analyzed and studied，and the influence of steel bar arrangement
CHENG Yunzhao, LIN Tao, DAI Qi, TAO Bing, LIAO Yi, YU Wenhai, LI Yinsong, LI Zhiming   +7 more
doaj   +1 more source

Quantifying Schedule Delay Risk in Construction Projects: A Data-Driven Approach with BIM and Probabilistic Reliability Analysis

Advances in Civil Engineering, 2023
Progress management is an important scheme of construction management. In practical affairs, many unknown factors may lead to potential project delays and make the schedule risky.
Shen Zhang, Xingyu Wang
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Generation Mechanisms of the Complex Adaptive System in Traditional Settlements: A Case Study of Zheshui Village, China

Buildings
Traditional villages embody tangible repositories of historical, cultural, and geographical heritage, and their sustainable and authentic development poses a global challenge.
Yunxing Zhang, Baien Zhang, Nana Han, Chenchen Lu, Jie Gao, Haidong Li, Feifei Zhai   +6 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Expanding the methods of human-VR interaction (HVRI) for architectural design process

26th International Conference of the Association for Computer-Aided Architectural Design Research in Asia (CAADRIA 2020), Online and Global – Organised from Hong Kong, 29.03 - 01.04.2021202505 bcchVersion of RecordOthers国家自然科学基金青年科学基金 The Young ...
Lin, C, Lo, TT
core   +1 more source