Results 41 to 50 of about 16,812 (314)
Fábio Moura Penteado in São Paulo. Drawings for a Modern, Urban, and Democratic Architecture
Drawings represent ideas and concepts, not just an architectural project. The concept of the ‘Architecture of the Crowd’ establishes principles of an architecture in which people are protagonists.
Letícia Bortolo Martins, Ana Tagliari
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Dutch Structuralism was an influential tendency in post-war Dutch architecture and urban design. Structuralist designs and buildings are made up of repetitive elements that can in theory be adjusted in both size and function.
Ellen Smit
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
THE SPIRITUAL CONSISTORY IN VLADIVOSTOK: ARCHITECTURAL PROJECTS AND IMPLEMENTATION
The article is devoted to the history of the architecture of pre-revolutionary Vladivostok and, in particular, its ecclesiastical consistory, the administrative office of the diocese. The publication is largely based on archival material from the Russian
Tolkacheva Albina A., Likhansky Yury I.
doaj +1 more source
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
This paper explores the dynamics through which design drawings structure spatial strategies, particularly those with an agenda for socio-political change, while interrogating the drawings’ impacts on subjectivity.
Hazem Ziada
doaj +3 more sources
Among the graphic collection of the Polish National Library's in Warsaw stands out “Wilanów Collection”, a part of Wilanów Library holdings, which were given to the National Library in 1932. It is noteworthy because of the substantive content, as well as
Katarzyna Garczewska-Semka
doaj +1 more source
What Do Large Language Models Know About Materials?
If large language models (LLMs) are to be used inside the material discovery and engineering process, they must be benchmarked for the accurateness of intrinsic material knowledge. The current work introduces 1) a reasoning process through the processing–structure–property–performance chain and 2) a tool for benchmarking knowledge of LLMs concerning ...
Adrian Ehrenhofer +2 more
wiley +1 more source
The paper combines a question about the architectural design project with the topics of future and utopia, through a series of drawings made all along the author’s career.
Franco Purini
doaj +1 more source

