Results 41 to 50 of about 4,478 (261)

An Automated Method of Parametric Thermal Shaping of Complex Buildings with Buffer Spaces in a Moderate Climate

Energies
This article presents a new method of parametric shaping of buildings with buffer spaces characterized by complex forms and effective thermal operation in the moderate climate of the Central Europe Plane.
Jacek Abramczyk, Wiesław Bielak, Ewelina Gotkowska   +2 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Metamorphoses of architectural graphics (the example of drawings of Smolensk’s fortress wall in the 18th -20th century)

Архитектон
One of the largest fortresses in the world, located in Smolensk, is in the line of textbook works of Russian architecture. Over the centuries, the architectural monument has been consistently regarded as a phenomenon of history, culture, architecture ...
Pilyak Sergey A.
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Aspects of Coexistence between Art Glass and Architecture—Façade Graphics

Arts
One of the key concerns for present-day society is the need to build the environment in which we live in a sustainable way, using green solutions, but without losing the aesthetic values.
Alina Lipowicz-Budzyńska
doaj   +1 more source

Architecture Diagrams: A Graphical Language for Architecture Style Specification [PDF]

Electronic Proceedings in Theoretical Computer Science, 2016
Architecture styles characterise families of architectures sharing common characteristics. We have recently proposed configuration logics for architecture style specification. In this paper, we study a graphical notation to enhance readability and easiness of expression.
Anastasia Mavridou, Eduard Baranov, Simon Bliudze, Joseph Sifakis   +3 more
openaire   +3 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

FROM THE BASICS OF SPATIAL CONSTRUCTIONS TO CONSTRUCTION OF AN IMAGE (A CASE STUDY OF ENGRAVINGS BY GIOVANNI BATTISTA PIRANESI)

Architecture and Engineering, 2016
The article deals with the exhibition “Piranesi. Before and After. Italy—Russia. XVIII–XXI Centuries” held at the Pushkin State Museum of Fine Arts in Moscow in autumn, 2016.
Elena Chernaya
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source