Results 51 to 60 of about 2,862 (253)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Aesthetical Appeal and Dissemination of Architectural Heritage Photographs in Instagram

Buildings, 2020
Image-based social networks are environments where users share their photographs and involuntarily contribute to evolve and to spread the meaning of things.
Vicente López-Chao, Vicente Lopez-Pena
doaj   +1 more source

Games@large graphics streaming architecture [PDF]

2008 IEEE International Symposium on Consumer Electronics, 2008
In coming years we will see low cost networked consumer electronics (CE) devices dominating the living room. Various applications will be offered, including IPTV, VoIP, VoD, PVR and others. With regards to gaming, the need to compete with PlayStation and Xbox will require a radical change in system architecture.
David, Haggai, Nave, Itay, Eisert, Peter, Fechteler, Philipp, Laikari, Arto, Shani, Alex, Tzruya, Yoav   +6 more
openaire   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Integrated Parametric Shaping of Curvilinear Steel Bar Structures of Canopy Roofs

Buildings, 2019
Shaping building objects is conditioned by many interrelated factors, both architectural and structural. Modern tools for shaping structures working in the environment of Rhinoceros 3D such as Grasshopper and Karamba 3D enable algorithmic-aided shaping ...
Jolanta Dzwierzynska
doaj   +1 more source

Architectural Design Guidelines Based on Computer Core Evaluation and Processing Paradigms

Engineering Proceedings, 2023
The architectural design process may utilize decision-making algorithms; usually, this takes a long time when using analog methods. Today, sequential processing (CPU) or parallel processing (GPU) works with architectural design in different ways, such as
Jose L. Reategui
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Inventive Methods in Conceptual Architectural Design

Education Sciences
In architectural design, the conceptual phase is of particular importance, as it plays a crucial role in achieving ambitious goals and creating valuable design concepts.
Igor Labuda, Jolanata Dzwierzynska
doaj   +1 more source

Rationalized Algorithmic-Aided Shaping a Responsive Curvilinear Steel Bar Structure

Buildings, 2019
The correlation of the architectural form and the structural system should be the basis for rational shaping. This paper presents algorithmic-aided shaping curvilinear steel bar structures for roofs, using modern digital tools, working in the environment
Jolanta Dzwierzynska
doaj   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source