Results 41 to 50 of about 851,649 (301)

Aesthetical Appeal and Dissemination of Architectural Heritage Photographs in Instagram

open access: yesBuildings, 2020
Image-based social networks are environments where users share their photographs and involuntarily contribute to evolve and to spread the meaning of things.
Vicente López-Chao, Vicente Lopez-Pena
doaj   +1 more source

An Engineering Graphics Application System [PDF]

open access: yes, 1992
EGAS is the acronym for the Engineering Graphics Application system, developed specifically to facilitate engineering design. It provides interactive drafting tools for civil engineering, mechanical engineering and architectural graphics, and is ...
Zhou, Hong
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

International Competition of Architectural Graphics

open access: yesПроект Байкал, 2019
The International Architectural Drawing Competition "Archigraphics” has become a regular event. In 2019 it was held for the sixth time already. The organizers emphasize that possession of graphic skills is a professional necessity for architects.
Marina Tkacheva
doaj   +2 more sources

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Integrated Parametric Shaping of Curvilinear Steel Bar Structures of Canopy Roofs

open access: yesBuildings, 2019
Shaping building objects is conditioned by many interrelated factors, both architectural and structural. Modern tools for shaping structures working in the environment of Rhinoceros 3D such as Grasshopper and Karamba 3D enable algorithmic-aided shaping ...
Jolanta Dzwierzynska
doaj   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

open access: yesMolecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi   +2 more
wiley   +1 more source

Inventive Methods in Conceptual Architectural Design

open access: yesEducation Sciences
In architectural design, the conceptual phase is of particular importance, as it plays a crucial role in achieving ambitious goals and creating valuable design concepts.
Igor Labuda, Jolanata Dzwierzynska
doaj   +1 more source

Rationalized Algorithmic-Aided Shaping a Responsive Curvilinear Steel Bar Structure

open access: yesBuildings, 2019
The correlation of the architectural form and the structural system should be the basis for rational shaping. This paper presents algorithmic-aided shaping curvilinear steel bar structures for roofs, using modern digital tools, working in the environment
Jolanta Dzwierzynska
doaj   +1 more source

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