Results 91 to 100 of about 25,746,526 (333)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Tracing the Morphogenesis and Formal Diffusion of Vernacular Mosques: A Typo-Morphological Study of Djebel Amour, Algeria

Buildings
The Djebel Amour region, located in the Western Saharan Atlas of Algeria, hosts a vernacular mosque heritage that remains largely unexplored. This study presents the first comprehensive typo-morphological analysis of fourteen mosques dating from the 11th
Sana Mekki, Bidjad Arigue, Giovanni Santi, Leila Sriti, Vincenzo Pace, Emanuele Leporelli   +5 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

AIGC-Driven HBIM modeling of dougong components for the Conservation of Qing dynasty architectural heritage

Journal of Asian Architecture and Building Engineering
This paper addresses the prominent issues of large workload in the 3D digital modeling of ancient Chinese wooden architectural components and the difficulty in achieving the dynamic inheritance of craftsmanship. It proposes a digital translation path for
Jun Cai, Jinliang Qu, Shengfeng Feng, Shengcai Xu, Shangsong Han, Yijian Liao, Wei He   +6 more
doaj   +1 more source

Quantitative Estimation of Missing Value Interpolation Methods for Suomi-NPP VIIRS/DNB Nighttime Light Monthly Composite Images

IEEE Access, 2020
Composited nighttime light (NTL) data are widely used to evaluate the intensity of human activities and estimate urban dynamics. However, due to the effects of stray light, Visible Infrared Imaging Radiometer Suite (VIIRS) monthly composited data are ...
Junfu Fan, Peng Zhang, Jiahao Chen, Bo Li, Liusheng Han, Yuke Zhou   +5 more
doaj   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Complex adaptive systems modeling with Repast Simphony

Complex Adaptive Systems Modeling, 2013
PurposeThis paper is to describe development of the features and functions of Repast Simphony, the widely used, free, and open source agent-based modeling environment that builds on the Repast 3 library.
M. North, Nicholson T. Collier, J. Ozik, E. Tatara, C. Macal, M. Bragen, P. Sydelko   +6 more
semanticscholar   +1 more source