Results 121 to 130 of about 228,900 (283)

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

A Comprehensive Study on Outdoor Thermal Comfort in Arid Urban Environments through Microclimatic Analysis of Urban Density

Buildings
Rapid urbanization across hot arid environments transforms local microclimates, yet linkages between density, layout, and outdoor thermal comfort remain inadequately characterized.
Alaa Eddine Bacha, Atef Ahriz, Mohammad Alshenaifi, Sultan Alfraidi, Emad Noaime, Badr Alsolami, Aritra Ghosh, Soumia Bouzaher, Lambros T. Doulos, Abdelhakim Mesloub   +9 more
doaj   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

Parametric Analysis as a Tool for Hypothesis Generation: A Case Study of the Federal Archive Building in New York City

Infrastructures
This study investigates the epistemological potentials of parametric analysis for digitally modeling ordinary, existing buildings, addressing a gap in architectural research.
Mike Christenson
doaj   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Architecture Quality Model

, 2023
The ability for a company’s IT solutions to adapt and grow with changing business needs continues to be a point of contention within the software industry. At an increasing rate, we see IT managers being challenged with modernizing and/or evolving large portions of their software landscape due to new business initiatives due to significant events (such
openaire   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Assessing the influence of PM2.5 and PM10 on subjective thermal comfort in university classrooms

Journal of Air Pollution and Health
Introduction: Indoor air quality plays a significant role in students' health and productivity. The present study attempts to examine the impact of air pollution on subjective thermal comfort and explores how the interaction between thermal conditions ...
Hadjira SAKHRI
doaj   +1 more source

Towards a Layered Architectural View for Security Analysis in SCADA Systems

, 2012
Supervisory Control and Data Acquisition (SCADA) systems support and control the operation of many critical infrastructures that our society depend on, such as power grids. Since SCADA systems become a target for cyber attacks and the potential impact of
Ma, Zhendong, Skopik, Florian, Smith, Paul   +2 more
core  

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source