Results 141 to 150 of about 25,746,526 (333)

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

P2PAM: a framework for peer-to-peer architectural modeling based on PeerSim

International ICST Conference on Simulation Tools and Techniques, 2008
Matteo Agosti, F. Zanichelli, M. Amoretti, G. Conte   +3 more
semanticscholar   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

An analysis of CAD use in Wisconsin architectural offices [PDF]

, 2008
Includes bibliographical ...
Kutrieb, Deborah M.
core  

An Intelligent Modeling Method for Protecting and Inheriting the Construction Techniques of Wooden Stilt Buildings

Buildings
This study examines the digital translation of traditional wooden architectural construction techniques through the application of Building Information Modeling (BIM) methods.
Jie Wu, Feng Chi, Yujiao Wei, Ye Zhao, Shuoyuan Huang, Hongtao Xu   +5 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

AFD-An Architectural Language for Integral Modeling

IEEE Access
Describing architectures of complex software systems using architectural languages is usually done through multiple viewpoints that enable the creation of views. While the creation of views enables the separation of stakeholders’ concerns with the
Stefan Tubic, Zaharije Radivojevic, Sasa Stojanovic, Milos Cvetanovic   +3 more
doaj   +1 more source

Architectural modeling of pixel readout chips Velopix and Timepix3

, 2012
T. Poikela, J. Plosila, T. Westerlund, J. Buytaert, M. Campbell, X. Llopart, R. Plackett, K. Wyllie, M. Beuzekom, V. Gromov, R. Kluit, F. Zappon, V. Zivkovic, C. Brezina, K. Desch, X. Fang, A. Kruth   +16 more
semanticscholar   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source