Results 121 to 130 of about 3,016,747 (301)

MLLMto3D: An MCP-Driven Closed-Loop Framework for Architectural 3D Generation

Buildings
Multimodal large language models can read architectural images and design instructions but they still struggle to turn architectural rules into editable, executable models in professional modeling environments.
Dong Yao, Bingcheng He, Xiaoxi Zhao
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

A Comprehensive Study on Outdoor Thermal Comfort in Arid Urban Environments through Microclimatic Analysis of Urban Density

Buildings
Rapid urbanization across hot arid environments transforms local microclimates, yet linkages between density, layout, and outdoor thermal comfort remain inadequately characterized.
Alaa Eddine Bacha, Atef Ahriz, Mohammad Alshenaifi, Sultan Alfraidi, Emad Noaime, Badr Alsolami, Aritra Ghosh, Soumia Bouzaher, Lambros T. Doulos, Abdelhakim Mesloub   +9 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Assessing the influence of PM2.5 and PM10 on subjective thermal comfort in university classrooms

Journal of Air Pollution and Health
Introduction: Indoor air quality plays a significant role in students' health and productivity. The present study attempts to examine the impact of air pollution on subjective thermal comfort and explores how the interaction between thermal conditions ...
Hadjira SAKHRI
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Automatic Removal of Non-Architectural Elements in 3D Models of Historic Buildings with Language Embedded Radiance Fields

Heritage
Neural radiance fields have emerged as a dominant paradigm for creating complex 3D environments incorporating synthetic novel views. However, 3D object removal applications utilizing neural radiance fields have lagged behind in effectiveness ...
Alexander Rusnak, Bryan G. Pantoja-Rosero, Frédéric Kaplan, Katrin Beyer   +3 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source