Results 41 to 50 of about 59,821 (310)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Architectural learning tool [PDF]
, 2002 Current trends in architectural education lean toward presenting and discussing the end product more than the process that leads to it. They equally highlight students' passive participation at the design studio practice.
Bakarman, Ahmed Abdullah
core
Crowdfunding & Architectural Practice
Ardeth, 2018 Young architectural practices are short of building opportunities, with limited knowledges of the production chain and access to potential investors among the relevant monetary aspects that deprive them from the practice of architecture as “the act of ...
Sheng Zhao
doaj
Heritage Science, 2023 Architectural heritage is a testament to human and natural development, and the process of human social development can be glimpsed through the study and exploration of heritage.
Ziyi Zhang, Yiquan Zou, Wei Xiao
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Designerly and entrepreneurial thinking in architectural practice: A case study of Al Stratford
Acta StructiliaTo remain resilient amid technological disruption and economic volatility, the architectural field must adopt entrepreneurial mindsets and methods. Design Thinking and Designerly Thinking have been the subject of comparison and analysis in the academic ...
Christo Vosloo
doaj +1 more source
AGG+, 2021 This paper deals with the importance of critical design practice in order to nurture, cultivate and build architectural culture. The main goal is to analyse the Memorial House in the Sutjeska National Park, designed by the architect Ranko Radović ...
Marina Radulj +2 more
doaj +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source