Results 61 to 70 of about 59,821 (310)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

A post-structural analysis of the architectural education - technology relationship [PDF]

open access: yes, 2004
This dissertation investigates how technology and architectural education relate to each other, in the broadest possible sense. What are the internal and external factors affecting our understanding and use of technology in architectural education?
Özersay, Fevzi
core  

Transferring architectural management into practice: A taxonomy framework

open access: yesFrontiers of Architectural Research, 2015
This research aimed to develop a unique framework to help architects understand and apply architectural management (AM) in their practices. A comprehensive literature review identified several components belonging to different specialist fields.
Mohammed Alharbi   +2 more
doaj   +1 more source

Software architecture: practice, potential, and pitfalls [PDF]

open access: yesProceedings of 16th International Conference on Software Engineering, 2002
A critical aspect of the design for any large software system is its gross structure – that is, its high-level organization of computational elements and interactions between those elements [3, 6]. Broadly speaking, we refer to this as the software architectural level of design.
David Garlan, Dewayne E. Perry
openaire   +2 more sources

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Reference Architecture Design: A Practical Approach [PDF]

open access: yesProceedings of the 13th International Conference on Software Technologies, 2018
Reference Architectures (RA) in a Software Product Line (SPL) context are generic schemas that can be instantiated to configure concrete architectures for particular software systems or products of the SPL family. SPLs claim to be reusable industrial solutions to reduce development cost and time to market; however their development requires a huge ...
Derras, Mustapha   +6 more
openaire   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Becoming an architect: the role of work-based learning in architect training.

open access: yes, 2013
This article examines the work-based placement of trainee architects in the United Kingdom to examine how trainees become architects. The trainee architects in this study experienced varying levels of participation and responsibility during their year ...
Orr, Kevin, Gao, Yun
core   +1 more source

Architectural Theory at Two Speeds

open access: yesArdeth, 2017
The article is a presentation of the ethnographic method applied to architecture. The author explains how “slow ethnographers” work when they deal with a building, by focusing on the case of namBa HIPS building by Shin Takamatsu, in Osaka.
Albena Yaneva
doaj  

Evolution of Practice in Undergraduate Architecture Education through Institutional Formations

open access: yesProceedings of the International Conference of Contemporary Affairs in Architecture and Urbanism-ICCAUA
Practice has always had an important place in the basis of architectural education, which exists with the mentoring system. With the influence of studio culture, practice has been relatively more prominent than theory in architecture undergraduate ...
Melike Nur Şahin
doaj   +1 more source

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