Results 81 to 90 of about 59,821 (310)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
, 2003 Overall view from the river bank, showing support hangers on each side of the arch; A road bridge spanning the River Clyde, connecting Finnieston, near the Clyde Auditorium and SECC with Pacific Quay and Glasgow Science Centre in Govan.
Halcrow Group Architectural Practice
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Leadership for a Sustainable Future: Insights from Civil Engineering and Architectural Professionals
Administrative SciencesThis study explores the extent to which civil engineers and architects in Spain perceive sustainable leadership practices in their organizations. The main aim is to understand how leadership approaches in the built environment sector can be aligned with ...
Elena Bulmer +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
The changing patterns of architectural design education
, 2008 Digital technologies have been introduced to students of architecture for over two decades and at present it could be argued that students are producing some of the highest quality designs, and some of the most interesting forms ever to come from ...
Horne, Margaret, Giddings, Bob
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Structure and Fragment in Architectural Practice
, 2022 Since the last decades of the previous century, image production has increased more rapidly than in any other history phase. The visual culture environment has become dominant and affected architectural practices.
Acar, Sibel +2 more
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Architectural Conservation In Brazilian Architecture And Urban Design Undergraduation Courses: The Teaching Disarticulations Between Theory And Project Practice [PDF]
, 2017 In the last two decades, discussions and methods of architectural conservation design have become more and more available in Brazil. However, in spite of this aparent development, heritage preservation still faces a minor impact over the general ...
Goncalves de Freitas +2 more
core +1 more source
Project Briefing in Russian Architectural Practice
Academia: Архитектура и строительство, 2018 Today both international and national documents, regulating architectural design, impute the responsibility of the architect for the development of project briefs ("technical assignments" or "design assignments"). To what extent the status quo in Russian
Konstantin V. Kiyanenko
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source