Results 51 to 60 of about 17,317 (266)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Method for selecting viewpoints of architectural heritage landscapes

Heritage Science
The selection of viewpoints is a crucial aspect in conducting visual impact assessments of architectural heritage. To address this issue, a quantitative viewpoint selection method based on GIS spatial analysis is proposed.
Yungang Hu, Yutang Feng, Ran Zhao, Yuhua Wu, Pinjun Nie   +4 more
doaj   +1 more source

Architecture for single iteration reconstruction algorithm [PDF]

2015 4th Mediterranean Conference on Embedded Computing (MECO), 2015
A hardware architecture for the single iteration algorithm is proposed in this paper. Single iteration algorithm enables reconstruction of the full signal when small number of signal samples is available. The algorithm is based on the threshold calculation, and allows distinguishing between signal components and noise that appears as a consequence of ...
Andjela Draganic, Irena Orovic, Nedjeljko Lekic, Milos Dakovic, Srdjan Stankovic   +4 more
openaire   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Dynamic Monitoring and Vibration Analysis of Ancient Bridges by Ground-Based Microwave Interferometry and the ESMD Method

Remote Sensing, 2018
In this paper, we propose to conduct a dynamic monitoring and vibration analysis of ancient bridges by means of ground-based microwave interferometry and the extreme-point symmetric mode decomposition (ESMD) method. Ground-based microwave interferometry,
Xianglei Liu, Zhao Lu, Wanxin Yang, Ming Huang, Xiaohua Tong   +4 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Research on the Hyperspectral-based Unmixing Model of Composite Pigments on Mural Surfaces [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences
Murals constitute an invaluable component of cultural heritage, encapsulating profound artistic and historical significance. Hyperspectral remote sensing, as a non-destructive testing technique, offers an effective means for analysing and identifying ...
Y. Zhang, Y. Zhang, S. Lyu, S. Lyu, M. Hou, M. Hou, J. Guo, J. Yan, J. Yan   +8 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

RESEARCH ON VISUALIZATION OF GROUND LASER RADAR DATA BASED ON OSG [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2018
Three-dimensional (3D) laser scanning is a new advanced technology integrating light, machine, electricity, and computer technologies. It can conduct 3D scanning to the whole shape and form of space objects with high precision.
H. Huang, H. Huang, H. Huang, C. Hu, C. Hu, C. Hu, F. Zhang, F. Zhang, F. Zhang, H. Xue, H. Xue, H. Xue   +11 more
doaj   +1 more source