Results 41 to 50 of about 17,548 (317)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Characteristics and Hazards of an Aeolian Sand Environment along Railways in the Southeastern Fringe of the Taklimakan Desert and Sand Control Measures

Applied Sciences, 2022
Based on wind velocity and wind direction data monitored by Qiemo and Ruoqiang Meteorological Stations, a systematic elaboration on the wind-sand hazards threatening railways in the study area is given.
Benteng Ma, Li Gao, Jianjun Cheng, Bosong Ding, Lusheng Ding, Lei Qu, Yuanfeng An   +6 more
doaj   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Fog Computing: A Comprehensive Architectural Survey

IEEE Access, 2020
Fog computing is an emerging technology to address computing and networking bottlenecks in large scale deployment of IoT applications. It is a promising complementary computing paradigm to cloud computing where computational, networking, storage and ...
Pooyan Habibi, Mohammad Farhoudi, Sepehr Kazemian, Siavash Khorsandi, Alberto Leon-Garcia   +4 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

A Multilevel Multiresolution Machine Learning Classification Approach: A Generalization Test on Chinese Heritage Architecture

Heritage, 2022
In recent years, the investigation and 3D documentation of architectural heritage has made an efficient digitalization process possible and allowed for artificial intelligence post-processing on point clouds.
Kai Zhang, Simone Teruggi, Yao Ding, Francesco Fassi   +3 more
doaj   +1 more source

A Survey on IoT Application Architectures

Sensors
The proliferation of the IoT has led to the development of diverse application architectures to optimize IoT systems’ deployment, operation, and maintenance. This survey provides a comprehensive overview of the existing IoT application architectures, highlighting their key features, strengths, and limitations. The architectures are categorized based on
Abdulkadir Dauda, Olivier Flauzac, Florent Nolot   +2 more
openaire   +4 more sources