Results 91 to 100 of about 2,251,534 (260)
NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement
Advanced Science, EarlyView.This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang +8 more
wiley +1 more source
The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis
Advanced Science, EarlyView.SLC39A13/ZIP13, a newly discovered intracellular iron transporter, delivers iron to the ER/Golgi to catalyze procollagen hydroxylation during collagen maturation. Here, we systematically characterize the cell type‐specific functions of ZIP13 across distinct hepatic cell populations, and identify hepatic stellate cell‐specific ZIP13 as a promising and ...
Shanshan Guo +5 more
wiley +1 more source
BuildingsThis study explores how integrating design processes into the native timber industry of southern Chile, specifically in the Araucanía and Los Ríos regions, can improve the value chain and promote sustainability.
Alejandra Schueftan +5 more
doaj +1 more source
Advanced Science, EarlyView.In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia +11 more
wiley +1 more source
Fotografías de la casa Santa Julia: Nicolás Rupcich
ARQ, 2012 Este registro fotográfico de una obra reciente en las afueras de Santiago construye un pequeño universo doméstico donde, por medio de la arquitectura, se encuentran el territorio, los ritos de la vida familiar y posesiones acumuladas en el tiempo.A set ...
Nicolás Rupcich, Emilio Marín
doaj
Análisis y diseño estructural de una edificación de seis niveles utilizando Revit y Etabs, Trujillo – 2022 [PDF]
, 2023 Nuestro proyecto de investigación tuvo como finalidad realizar el análisis y diseño estructural de una edificación de seis niveles utilizando los softwares Revit y Etabs en la ciudad de Trujillo, se logró realizar la interoperabilidad BIM entre los ...
Quezada Rodriguez, Carlos Alberto +1 more
core
Comparative Single‐Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits
Advanced Science, EarlyView.A cross‐species single‐cell transcriptomic atlas of reproductive and central nervous system tissues from sheep and humans reveals conserved cellular programs and regulatory networks that regulated fertility. Integration with GWAS for sheep lifetime average litter size identifies UNC5–SLIT–BMP signaling as a core pathway coordinating neuroendocrine ...
Bingru Zhao +8 more
wiley +1 more source
Sobre principios de la representación arquitectónica
ARQ, 2006 La distancia de Chile a los centros tradicionales de la cultura arquitectónica, lejos de limitar el desarrollo local, le ha conferido carácter y temple.
Lorena Valdivia
doaj
Project Vicissitudes. Private ironism and critique of ideologies
Materia Arquitectura, 2013 The virtual discredit of the modern notion of “project” as a rational achievement of an emancipatory political telos emerges as a counterface of the persistent reduction of the project exercise to the significant plan of representation resources, an ...
José Solís
doaj +1 more source
Advanced Science, EarlyView.This study repurposes mitochondrial DNA mutations as endogenous barcodes for lineage tracing in human pluripotent stem cell‐derived organoids. Integrated with transcriptomic and spatial data, it reveals NOTCH‐mediated stromal‐progenitor crosstalk orchestrates clonal dynamics and spatial zonation during early hematopoietic development, offering a non ...
Yan Xue +17 more
wiley +1 more source