Results 51 to 60 of about 8,772 (217)

Addressing Water Scarcity in Isla Huichas, Chile: A Tecno-Economic Sustainable Solution

World
Islas Huichas, located in Chile’s remote Aysén region, has long faced water scarcity due to a lack of natural sources. The community relies on rainwater collection pools managed by the Rural Drinking Water Committee (RDWC), which face increased pressure ...
Benjamín Borquez, José Ahumada, Michael Mendoza, Renny Guillén, Victor Contreras   +4 more
doaj   +1 more source

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

Reinforcement Learning-Driven Negotiation in a Multi-Agent System for Truck Dispatching in Open-Pit Mining

Applied Sciences
Material handling is an important process in open-pit mining, where trucks transport material extracted by shovels to different destinations within the mine.
Otthein Herzog, Gabriel Icarte-Ahumada, Daniel Arratia, Cristian Lucero   +3 more
doaj   +1 more source

Oxygen Vacancy‐Enriched Platinum Single‐Atom Nanozyme Wrapped in Nanoislands: Unlocking Catalytic Activity and Reprogramming Redox Microenvironment for Osteonecrosis Repair

Advanced Science, EarlyView.
CeO2‐x/Pt single‐atom nano‐island is constructed via low‐temperature reduction, featuring abundant oxygen vacancies and an island–sea structure. It delivers outstanding multi‐enzyme‐mimetic activity and ROS‐scavenging efficiency. Density functional theory reveals optimized electronic structures and reaction pathways.
Yang Zhu, Zehui Lv, Xuejie Cai, Penghui Wei, Dengliang Wang, Zhao Wang, Ruoying Wang, Yingjie Wang, Xingdong Yang, Yixin Bian, Jiawei Xu, Xisheng Weng, Liangfeng Wei   +12 more
wiley   +1 more source

The Lifestyles of Space Standards: Concepts and Design Problems

Urban Planning
Space standards are envisioned as a powerful means to regulate dwelling design, ensuring the quality, functionality, and safety of homes. Their ultimate objective is to guarantee a minimum level of design quality that can accommodate a wide range of ...
Alvaro Arancibia
doaj   +1 more source

An Integrated DNA Nanoprobe for Intranuclear Imaging and in Situ Profiling of OGG1 Activity

Advanced Science, EarlyView.
The TP‐SA nanoprobe, integrating an AS1411 aptamer for nuclear delivery and a FRET array for signal amplification, enables real‐time tracking of nuclear OGG1 activity. It reveals cell‐line‐specific basal OGG1 levels and shows clinical promise using pneumonia patients’ lavage fluid.
Mingzhu Zhao, Xuemei Sun, He Li, Bangming Wang, Mengting Pan, Zhen Ma, Rong‐Mei Kong, Weiheng Kong, Yan Zhao, Fengli Qu   +9 more
wiley   +1 more source

Centralized Evolutionary Optimization and Decentralized Agent-Based Scheduling for Open-Pit Mine Dispatching

Applied Sciences
Truck dispatching in open-pit mining is an important process with a direct impact on productivity, equipment utilization, and hauling cost. While this problem is often treated as a sequence of isolated allocation decisions, a scheduling perspective makes
Gabriel Icarte-Ahumada, Manuel Goyo, Victor Godoy, Otthein Herzog   +3 more
doaj   +1 more source

Architectural representation and project critique. New fields of meaning

Materia Arquitectura, 2014
The paper introduces a discussion framework about the representation concept in architecture. This approach proposes that the validity of the representation strategies is based on its capacity to link the discursive field (theory) with the operating ...
Felipe Corvalán
doaj   +1 more source

Single‐Cell Annotation and Localization via Integrating Spatial Transcriptomics Maps the Mouse Ocular Atlas and RAO Dynamics

Advanced Science, EarlyView.
We developed the ASCAL pipeline, integrating complementary spatial transcriptomics, to construct a high‐fidelity mouse whole‐eye single‐cell atlas. Applying ASCAL to a retinal artery occlusion (RAO) model revealed spatially restricted immune activation localized to the ganglion cell layer and the selective depletion of a translationally active, outer ...
Chen Du, Yinming Li, Ziyue Li, Yuedan Wang, Shaopeng Li, Yijie Wang, Yingying Qu, Bingyang Lv, Ying Li, Ting Chen, Yu Zhou, Xuan Xiao   +11 more
wiley   +1 more source

A Disaggregation Strategy for Nanopesticide Fabrication: Investigating the Impact of Nanosizing on Pesticide Biointeractions

Advanced Science, EarlyView.
To explore the impact of nanosizing on pesticide biointeractions, a 7‐nm (average) emamectin benzoate nanopesticide without nanocarriers or surfactants is fabricated via HOAc‐mediated disaggregation. Nanosizing enhances bioactivity against Megalurothrips usitatus and Meloidogyne enterolobii and improves plant penetration.
Jiaqi Wei, Jianxin Feng, Huiting Zhu, Kunzhong Lin, Chenhan Liu, Lin Li, Zhuoyan Xiao, Daihao Huang, Rong Liu, Huipeng Pan, Lingda Zeng, Hanhong Xu   +11 more
wiley   +1 more source