Results 101 to 110 of about 2,489,657 (327)

The hidden biotic face of microbialite morphogenesis – a case study from Laguna de Los Cisnes, southernmost Patagonia (Chile)

Sedimentology
Microbialites provide geological evidence into Earth's early ecosystems, recording long‐standing interactions between co‐evolving life and the environment.
Clément Pollier, Alejandro N. Guerrero, Jorge Rabassa, D. Ariztegui   +3 more
semanticscholar   +1 more source

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

Concepción 1960, Concepción 2018. Refotografía del archivo GOYCOOLEA I.

Arquitecturas del Sur, 2018
El refotografiado surge en el siglo XIX - Finsterwalder lo utilizó por primera vez en 1888 para el estudio de glaciares (Webb, 2010) - como estudio científico para observar las transformaciones del territorio.
Nicolás Sáez Gutiérrez
doaj  

Estimating the tolerance of species to the effects of global environmental change

, 2013
Global environmental change is affecting species distribution and their interactions with other species. In particular, the main drivers of environmental change strongly affect the strength of interspecific interactions with considerable consequences to ...
Bascompte, Jordi, Dakos, Vasilis, Rohr, Rudolf P., Saavedra, Serguei   +3 more
core   +3 more sources

Targeted Degradation of eEF2K by a Structure‐Guided PROTAC Strategy for the Treatment of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao, Changxin Zhong, Shilong Jiang, Yungui Li, Yang Xi, Mingxuan Xiao, Ting Jiang, Xiaoya Wan, Zonglin Chen, Xiaohui Yu, Yan Cheng   +10 more
wiley   +1 more source

Cascade‐Responsive MXene@Cu‐MOF Heterostructure Integrates Antioxidant Activity, Infection Control, and Vascularization for Tracheal Repair

Advanced Science, EarlyView.
A cascade‐responsive MXene@Cu‐MOF/GelMA hydrogel is engineered as a “skeleton–backpack” platform for extensive tracheal repair. The MXene framework scavenges postoperative ROS and converts NIR light into mild hyperthermia, while the Cu‐MOF component provides pH/NIR‐responsive Cu2+ dosing for infection control, angiogenesis, and chondrogenesis.
Liang Guo, Yingran Shen, Jiaoyu Yi, Juanjuan Li, Ziming Wang, Erji Gao, Siqiang Zheng, Zhe‐Sheng Chen, Bo Tao   +8 more
wiley   +1 more source

Designing Scalable Mechano‐Virucidal Nanostructured Acrylic Surfaces for Enhanced Viral Inactivation

Advanced Science, EarlyView.
Can a surface be designed to physically break viruses? This study explores how nanoscale geometry—specifically the spacing of tiny pillars—can determine whether viruses remain intact or rupture. Using flexible acrylic and a scalable fabrication process, the authors develop nanopillared, transparent surfaces that show strong antiviral activity without ...
Samson W. L. Mah, Denver P. Linklater, Vassil Tzanov, Chaitali Dekiwadia, Sergey Rubanov, Phuc H. Le, Laleh Tafakori, Ranya Simons, Graeme Moad, Soichiro Saita, Takashi Yanagishita, Hideki Masuda, Vladimir Baulin, Natalie A. Borg, Elena P. Ivanova   +14 more
wiley   +1 more source

Sumario

Revista Hábitat Sustentable, 2022
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Hábitat Sustentable
doaj  

A “Hot Spring” Mimetic Aerogel Loaded with Multiple Amino Acids Modulates the Chronic Inflammatory Microenvironment Through Metabolic Reprogramming

Advanced Science, EarlyView.
The SrCuSi4O₁₀ bioceramic particles mimic the effects of hot spring therapy by increasing the local wound temperature, which enhances the absorption of amino acids and stimulates cell metabolism. The amino acid uptake supports cellular glutathione redox reactions, helping to mitigate oxidative stress.
Bo Li, Dandan Jin, Fei Li, Jianliang Shen, Jiang Chang, Chen Yang, Shixuan Chen, Yi Zhang   +7 more
wiley   +1 more source

Depositional processes and stratigraphic evolution of the Campanian deltaic system of La Anita Formation, Austral-Magallanes Basin, Patagonia, Argentina [PDF]

, 2019
Coastal depositional systems are commonly classified in terms of the relative interaction of wave, tide and fluvial processes. The La Anita Formation represents the opportunity to study and better understand coastal sedimentary systems.
Cereceda, Abril, Moyano Paz, Damián, Poire, Daniel Gustavo, Tettamanti, Camila, Varela, Augusto Nicolás   +4 more
core   +2 more sources