Results 71 to 80 of about 2,478,474 (334)

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Multi-source qualitative analysis of emergency medicine residency programmes in Chile: A case studyAnálisis cualitativo de múltiples fuentes de programas de residencia en Medicina de Urgencia en Chile: un estudio de caso

© 2023 The AuthorsBackground: Emergency medicine (EM) is a developing specialty worldwide. In Chile, it has been developing for 25 years, however, there is a need for further progress. Aim: We aimed to explore the current postgraduate curriculum in Chile
Basauri S., Scanlan G.M., Muir F.
core   +1 more source

Urban waterfront rehabilitation in Pelluhue County, Chile affected by the Chile 2010 earthquake and tsunami [PDF]

, 2014
During the morning of February 27th, 2010, a strong earthquake with a magnitude of 8.8Mw affected the central region of Chile. As a result of the earthquake, tsunami waves were generated.
Igualt, Felipe Eduardo
core  

Lo bello o lo útil. Ideologías en disputa en torno a la creación del primer curso universitario de arquitectura en Chile, 1848-1853

, 2018
In 1849 the first university architecture course in Chile was founded at the University of Chile. Although local historiography has established that the orientation of the course was, at its roots, Beaux-Arts style this term had certainly not been ...
Peliowski, Amari [Univ Mayor, Fac Artes, Ctr Invest Artes & Humanidades, Santiago, Chile]
core   +1 more source

EDITORIAL. De Los límites del crecimiento a los límites de densidad

Urbano, 2018
En 1972 el Club de Roma solicitó al MIT la elaboración de un informe conocido como el Informe Meadows o Los límites del Crecimiento. Sus conclusiones plasman, por primera vez en la historia de la humanidad, la grave crisis ecológica a la que el ser ...
ANA ZAZO-MORATALL, IGNACIO BISBAL-GRANDAL   +1 more
doaj   +1 more source

Neoliberalismo, covid19 y su impacto en la academia desde una perspectiva de género

Urbano, 2020
El COVID19 ha profundizado brechas preexistentes en muchos ámbitos que, aunque ya conocidas, se han relevado como claves en la cotidianeidad de los últimos meses.
Ana Zazo-Moratalla
doaj   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

Identifying competencies for emergency medicine in Chile: Modified Delphi techniqueIdentificación de competencias para la medicina de urgencia en Chile: técnica Delphi modificada

© 2024 The Author(s)Emergency Medicine (EM) in Latin America and other Spanish-speaking regions is in a stage of development, especially in Latin America and other Spanish speaker populations.
Brinkmann Bizama M., Acuna Roberts L., Basauri Savelli S., Garrido Valdebenito M., Pinto Espinosa F.   +4 more
core   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source