Results 91 to 100 of about 11,327,595 (293)
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Design of network management and regulation system over flexible reconfiguration
Tongxin xuebao, 2012 Network management and regulation system is a new arising appliance for the manageable,controllable and trustworthy demand of the Internet.The architecture design of the backbone link-level management and regulation system usually follows the core router,
Yu-feng LI +3 more
doaj
Experimentation in architecture: Pavilion design
, 2020 Since the Great Exhibition in London in 1851, the field of exhibition design has become an inevitable impact on both architectural practice and discourse.
Tunçbilek, Gonca Zeynep
core
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
, 2008 Overall view; At 258 metres (846 ft) in height it is the second tallest tower in the city after the Central Radio & TV Tower, and the fourth-tallest structure in the city.
China Architecture Design & Research Group
core
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Moscow Agglomeration: the 1st Stage of the Competition
Проект Байкал, 2012 - Strelka Institute for Media, Architecture and Design
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
SRAM-Based CIM Architecture Design for Event Detection. [PDF]
Sensors (Basel), 2022 Sulaiman MBG +5 more
europepmc +1 more source