Results 71 to 80 of about 11,327,595 (293)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Association between public space and resident outdoor activity behavior in urban areas surrounding lakes

Scientific Reports
This study integrates Behavior Setting Theory with GIS spatial analysis to elucidate the association between public space characteristics and resident outdoor activity behavior in urban areas surrounding lakes, using Nanchang’s Qingshan Lake as a case ...
Fan Liya, Lai Yuqing, Hu Zhouni, Zheng Wenhui, Zhou Tao   +4 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Harnessing Deep Learning and Reinforcement Learning Synergy as a Form of Strategic Energy Optimization in Architectural Design: A Case Study in Famagusta, North Cyprus

Buildings
This study introduces a novel framework that leverages artificial intelligence (AI), specifically deep learning and reinforcement learning, to enhance energy efficiency in architectural design.
Hirou Karimi, Mohammad Anvar Adibhesami, Siamak Hoseinzadeh, Ali Salehi, Daniele Groppi, Davide Astiaso Garcia   +5 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Designing an effective educational toy: incorporating design-thinking in the design classroom

Discover Education
“Designing an effective educational toy” is a research project that emerged from a teaching and learning course designed to facilitate creative engagement both inside and outside the classroom at Wenzhou-Kean University in China.
Natalie Houston, Ferney Manrique, Shi Mo, Wang Ruoqian, Ji Wenjing, Lu Yuting   +5 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Assessing elderly walkability to urban parks using mobility analysis and multi-source data: a case study of central Fuzhou, China

Scientific Reports
Ensuring equitable park access amid rapid urbanization and population ageing is essential. We propose an integrated framework that couples street-network impedance modelling with streetscape visual perception to assess elderly walkability to parks in ...
Min Wu, Kaige Zheng, Junhong Chen, Jiaxin Zhang, Mingfei Li, Shihang Wu   +5 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Vertical Design Studio Experience in Interior Architecture Education

, 2018
Design studios are at the core of interior architecture education. Environments where “learners form their own learning” enhance the communication between the teacherlearner, and learner–learner.
Yücesan, Ebru, Ozar, Betül, ÖZBEK, DERYA ADIGÜZEL, Melikoğlu Eke, Armağan Seçil   +3 more
core   +1 more source