Results 61 to 70 of about 11,327,595 (293)
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
BuildingsAdaptive construction techniques in traditional vernacular dwellings play an important role in improving the wind–thermal microclimate of buildings. However, comparative studies on such techniques across different regions remain limited.
Zhiyi Zhou +8 more
doaj +1 more source
Evaluating Design Rationale in Architecture
2019 IEEE International Conference on Software Architecture Companion (ICSA-C), 2019 Although architecture is often seen as the culmination of design decisions, design rationale is a suppositious child in architecture documentation. Many architecture frameworks and standards, like TOGAF and ISO/IEC 42010, recognize the importance, but do not offer any support in the rationale process.
Pim De Jong +4 more
openaire +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Quo Vadis Architectura? 8 - Nils Erik Wickberg lectures
, 2020 The Department of Architecture at Aalto University has organized annual Nils Erik Wickberg lectures since 2005 to honour his legacy. Professor Wickberg was an architect, architectural historian, and multi-talented ideologist. This book comprises lectures
Helander, Vilhelm +7 more
core +1 more source
System architecture design [PDF]
Artificial Intelligence for Engineering Design, Analysis and Manufacturing, 2016 Eckert, Claudia, Jankovic, Marija
openaire +4 more sources
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Implementing resource discovery techniques at the Museum of Domestic Design and Architecture, Middlesex University [PDF]
, 2015 This paper is a report on a Jisc-funded project at the Museum of Domestic Design and Architecture aimed at assessing the use of Social Media in combination with a Balanced Value Impact ...
Smith, S. +3 more
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