Results 41 to 50 of about 2,804,512 (374)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Volatile aldehydes in libraries and archives [PDF]

open access: yes, 2010
Volatile aldehydes are produced during degradation of paper-based materials. This may result in their accumulation in archival and library repositories. However, no systematic study has been performed so far.
Cassar, M.   +8 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Strategies for Implementing a Mass Digitization Program [PDF]

open access: yes, 2014
[Excerpt] In 2007, OCLC published the report Shifting Gears: Gearing Up to Get Into the Flow to bring to the forefront a much needed conversation about digitization of archival collections, and access to the rich content accessible only through paper or ...
Moore, Erik
core   +1 more source

The archive of Marie-Louise Bastin: archival description

open access: yesBoletim do Arquivo da Universidade de Coimbra, 2021
O presente artigo tem por objetivo dar a conhecer a documentação/informação do arquivo de Marie-Louise Bastin (MLB), atualmente custodiado pelo Departamento de Ciências da Vida da Faculdade de Ciências e Tecnologia da Universidade de Coimbra e pelo Museu da Ciência da mesma universidade.
Gomes, Liliana Isabel Esteves   +2 more
openaire   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

La descripción del productor y los registros de autoridades en los contextos archivísticos

open access: yesRevista Interamericana de Bibliotecología, 2016
La representación de la información en el ámbito de los archivos enfrenta nuevos desafíos marcados por las transiciones paradigmáticas de la Archivística.
Dunia LLanes Padrón   +1 more
doaj   +1 more source

Using Google Analytics Data to Expand Discovery and Use of Digital Archival Content [PDF]

open access: yes, 2013
This article presents opportunities for the use of Google Analytics, a popular and freely available web analytics tool, to inform decision making for digital archivists managing online digital archives content.
Szajewski, Michael
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

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