Results 171 to 180 of about 12,829,435 (259)

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

Spatial transcriptomic profiling of porcine tissue microarray detecting subclinical circovirus infection. [PDF]

Front Vet Sci
Kim W, Song S, Cho H, Park JE, Oh T.
europepmc   +1 more source

Engineered Transformer Base Editor with Enhanced Editing Efficiency

Advanced Science, EarlyView.
A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen, Letong Liang, Rui Xu, Tianyi Wang, Hongyan Chen, Daru Lu   +5 more
wiley   +1 more source

Programmable Information Processing With Reconfigurable Self‐Contact Variable Stiffness Mechanical Metamaterial

Advanced Science, EarlyView.
Reconfigurable self‐contact variable stiffness metamaterials based on shape memory polymers enable programmable stiffness switching. Static arrays store and encrypt information with immunity to electromagnetic interference, while asymmetric stiffness converts symmetric vibration into directional matter transport.
Huadong Qin, Wenyu Zhu, Xin Wang, Cheng Shen, Li Cheng, Tian Jian Lu, Terence Xiaoteng Liu, Han Meng   +7 more
wiley   +1 more source

Felty Syndrome-Associated Clonal Cytotoxic T-Cell Disease With Terminal Aggressive Progression: Shared <i>STAT3</i> and <i>TET2</i> Mutations Across a Prolonged Disease Course. [PDF]

EJHaem
Saito K, Yokohama A, Kwan Ee O, Sorimachi M, Imamura K, Kobayashi N, Miyazawa Y, Ogawa Y, Saito T, Shirakura T, Nobusawa S, Handa H.   +11 more
europepmc   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Dynamic HER2 reassessment and precision sequencing after trastuzumab in HER2-positive advanced gastric cancer. [PDF]

ESMO Gastrointest Oncol
Ooki A, Shimozaki K, Yamaguchi K.
europepmc   +1 more source

CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome

Advanced Science, EarlyView.
By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen, Zhiquan Liu, Wenmin Wang, Qing Wang, Tia J. Kowal, Fan Zhang, Grzegorz Walkiewicz, Faruk Hossen, Herbert M. Lachman, Jinqiong Zhou, Yiting Wang, Yang Sun   +11 more
wiley   +1 more source

Communications Workers of America Akron Branch finding aid_SVFedits2

The records of the Communications Workers of America, Local 4302, contain materials relating to the activities of Local 4302 in the Akron area and its relationships with other CWA organizations, both within Ohio and at the national level and with AFL-CIO
Archival Services
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<i>FGFR3</i> gene alteration and protein expression in upper urinary tract carcinoma: unsuitability of ureteroscopic biopsy specimens for <i>FGFR3</i> RNA testing. [PDF]

Explor Target Antitumor Ther
Miyake M, Oda Y, Nishimura N, Ohnishi S, Miyazaki K, Shimizu T, Owari T, Iida K, Fujimoto K.   +8 more
europepmc   +1 more source