Advanced Science, EarlyView.This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai +12 more
wiley +1 more source
A Cloud-Aware Scalable Architecture for Distributed Edge-Enabled BCI Biosensor System. [PDF]
Biosensors (Basel)Ghosh S +7 more
europepmc +1 more source
AI‐Physics‐Experiment Trinity for Integrated Protein Dynamics Modeling
Advanced Science, EarlyView.This review unites experiments, physics‐based simulations, and AI as a synergistic triad for protein dynamics modeling. It highlights integrative strategies, resolves sampling and forcefield bottlenecks, and outlines challenges and future directions for accurate, interpretable conformational ensemble prediction.
Chen Shi +4 more
wiley +1 more source
Quality Assessment of Box Materials for Long-Term Archival Storage: VOC Emissions Are Not a Significant Concern. [PDF]
ChempluschemDeraz R +7 more
europepmc +1 more source
Synergistic HMGN1 and VP64 Fusions Potentiate High‐Precision and PAM‐Flexible Base Editing
Advanced Science, EarlyView.A novel CDA1Δ‐SpRY architecture fused with HMGN1 and VP64 yields a nearly PAM‐less base editing platform. By focusing cytosine conversion predominantly at position −18, this synergistic complex ensures highly precise targeting. Demonstrating enhanced efficiency across diverse models, including yeast and rice, the platform offers a robust solution for ...
Xi Luo +11 more
wiley +1 more source
Restorative Justice and Sexual Assault: An Archival Study of Court and Conference Cases
, 2006 Kathleen Daly
semanticscholar +1 more source
Sant'Andrea della valle dataset: Georeferenced 2D study models of a Theatine Church. [PDF]
Data BriefBianchini C +4 more
europepmc +1 more source
How Proton Incorporation Reshapes Lattice Dynamics In BaSnO3‐Type Proton Conductors
Advanced Science, EarlyView.Yttrium‐doped BaSnO3 exhibits isotope‐dependent changes in its low‐energy vibrational density of states upon hydration. Comparison of dry, H2O‐, and D2O‐treated samples re‐veals mass‐dependent phonon renormalization linked to proton dynamics near oxygen va‐cancies, providing experimental insight into hydrogen‐coupled lattice excitations in proton ...
Artur Braun +9 more
wiley +1 more source
Historical Range Contraction and Extent of Harbour Porpoises (<i>Phocoena phocoena</i>) in the Baltic Sea Revealed by Archival Newspapers. [PDF]
Ecol EvolAiken M +3 more
europepmc +1 more source
Placental Site Trophoblastic Tumor Acquires Immune Functions by Incorporating Host Maternal Genes
Advanced Science, EarlyView.PSTT cells, through cell fusion with B cells, incorporate abundant non‐inherited maternal genes that are detectable by DNIMA. These hybrid cells acquire immunotherapy‐resistant genetic changes and increase the expression of B cell‐derived immune‐related molecules such as Ig, HLA, LILRB, SIGLEC10, and so on, creating an immunotolerant environment around
Kyosuke Kagami +15 more
wiley +1 more source