Results 41 to 50 of about 41,119,821 (305)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

A implantação da lei de acesso à informação pública e a gestão da informação arquivística governamental │ Access to Public Information Act: implementation and the management of government archival information

Liinc em Revista, 2013
Resumo São identificados e analisados aspectos relativos à implantação da Lei de Acesso à Informação Pública - LAI (Lei no 12.527, de 18 de novembro de 2011), considerando-se a sua regulamentação nos Poderes Executivos Federal, de 15 Estados e do ...
José Maria Jardim
doaj   +1 more source

Changes in the settlement network in the Noteć Forest (Poland) in a historical perspective

Journal of Maps, 2021
The article concerns the utilisation of existing cartographic materials and spatial databases for an analysis and visualisation of changes in land usage which occurred in the Noteć Forest. From the year 1700, small settlements began to spring up on these
Radzym Ławniczak, Jarosław Kubiak
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Utilizing AI Assistants in Social Science Research: A Methodological Case Study of AI-Assisted Archival Research on Acid-Attack Violence

Social Sciences
The rapid evolution of generative artificial intelligence (AI) is substantially changing archival research methodologies in social sciences. Yet, more structured guidance of methodological protocols informing AI use is needed to mitigate emergent threats
Jessi Hanson-DeFusco
doaj   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

The Use of Generative Artificial Intelligence in the Digitisation of Printed and Manuscript Documents and Its Contribution to Historical and Archival Education

Pedagogika
Objectives: This study examines how contemporary generative language models can support archival and historical work with Czech handwritten texts, focusing on transcription and basic preliminary analysis, and it outlines key limitations and ethical ...
Klára Rybenská, Sylva Sklenářová
doaj   +7 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source