Results 51 to 60 of about 25,687,323 (301)

A Study of the Use of Unrestricted Health Information in Digitized Medical Archival Collections [PDF]

, 2019
There are significant concerns for those working in medical archives, health sciences collections, and history of medicine collections regarding the provision of online access to medical records.
Almond, Sarah
core   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

A implantação da lei de acesso à informação pública e a gestão da informação arquivística governamental │ Access to Public Information Act: implementation and the management of government archival information

Liinc em Revista, 2013
Resumo São identificados e analisados aspectos relativos à implantação da Lei de Acesso à Informação Pública - LAI (Lei no 12.527, de 18 de novembro de 2011), considerando-se a sua regulamentação nos Poderes Executivos Federal, de 15 Estados e do ...
José Maria Jardim
doaj   +1 more source

Changes in the settlement network in the Noteć Forest (Poland) in a historical perspective

Journal of Maps, 2021
The article concerns the utilisation of existing cartographic materials and spatial databases for an analysis and visualisation of changes in land usage which occurred in the Noteć Forest. From the year 1700, small settlements began to spring up on these
Radzym Ławniczak, Jarosław Kubiak
doaj   +1 more source

Secondary adoption of technology standards: The case of PREMIS [PDF]

, 2013
While archival scholars have identified some of the most important steps for deciding to use and implement metadata standards in archives, very little systematic empirical investigation within the archival science literature regards either how ...
Yakel, Elizabeth, Elizabeth Yakel, Devan Ray Donaldson, Donaldson, Devan Ray   +3 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

The Use of Generative Artificial Intelligence in the Digitisation of Printed and Manuscript Documents and Its Contribution to Historical and Archival Education

Pedagogika
Objectives: This study examines how contemporary generative language models can support archival and historical work with Czech handwritten texts, focusing on transcription and basic preliminary analysis, and it outlines key limitations and ethical ...
Klára Rybenská, Sylva Sklenářová
doaj   +7 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source