Results 31 to 40 of about 418,373 (300)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Genealogy in the System of Modern Knowledge: Theory and Methodology of Cognitive History of O.M. Medushevskaya

RUDN Journal of Russian History
The author analyzes the place of genealogy as a unique indicator of humanitarian culture both in historical retrospect and modern society, since the subject of its study has traditionally been universal human values - family, kinship and relationships ...
Irina V. Sabennikova
doaj   +1 more source

Report of the DELAMAN Costing Case Study [PDF]

, 2014
DELAMAN member archives estimated the costs of archiving two sample deposits of language documentation data. Comparing these costs to the cost of funding a documentation project which would generate this amount of data, the costs of archiving can be ...
Digital Endangered Languages and Musics Archiving Network
core  

Enforcing public data archiving policies in academic publishing: A study of ecology journals

, 2018
To improve the quality and efficiency of research, groups within the scientific community seek to exploit the value of data sharing. Funders, institutions, and specialist organizations are developing and implementing strategies to encourage or mandate ...
Boettiger, Carl, Katz, Daniel S., Ram, Karthik, Sholler, Dan   +3 more
core   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Event Notifications and Event Logs

International Journal of Digital Curation
The “Event Notifications in Value-Adding Networks” specification provides an interoperable fabric that can be used in scholarly communication to exchange messages among data nodes that make scholarly artifacts available to the network and service nodes ...
Patrick Hochstenbach, Ruben Verborgh, Herbert Van de Sompel   +2 more
doaj   +1 more source

Digital Archaeological Archiving in Baden-Württemberg, Germany: an evolving system

Internet Archaeology, 2021
Since 2005, the Landesamt für Denkmalpflege Baden-Württemberg has been collecting semi-structured archaeological digital project data with the aim of one day turning that data into a real long-term digital archive. This process is still ongoing.
David Bibby
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Archiving of Archaeological Digital Datasets in Slovenia: historic context and current practice

Internet Archaeology, 2021
This article presents the archiving of archaeological digital datasets in Slovenia in its historic context. The datasets discussed have been separated into three categories: non-reproducible datasets, reproducible datasets, and registries.
Benjamin Štular
doaj   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source