Results 41 to 50 of about 418,373 (300)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Design of an Archiving Information System using the Agile Scrum Method

Sistemasi: Jurnal Sistem Informasi
This study aims to design and implement a web-based archiving information system at PT Sarana Tirta Ungaran using the Agile Scrum methodology. The background of this research lies in the challenges of manual archive management, which often lead to ...
Denny Farissa Setiawan, Yani Rahardja
doaj   +1 more source

Towards a national web in a federated country : a Belgian case study [PDF]

, 2016
Although the .be domain was introduced in June 1988, the Belgian web is currently not systematically archived. As of August 2016, 1.550.147 domains are registered by DNS Belgium.
Chambers, Sally, Depoortere, Rolande, Isbergue, Nadège, Mechant, Peter, Vandepontseele, Sophie   +4 more
core  

Cherenkov Telescope Array Data Management [PDF]

, 2015
Very High Energy gamma-ray astronomy with the Cherenkov Telescope Array (CTA) is evolving towards the model of a public observatory. Handling, processing and archiving the large amount of data generated by the CTA instruments and delivering scientific ...
Aboudan, A., Antonelli, L. A., Arrabito, L., Barbier, C., Bastieri, D., Boisson, C., Brau-Nogué, S., Bregeon, J., Bulgarelli, A., Carosi, A., consortium, for the CTA, Contreras, J. L., Costa, A., De Cesare, G., Fioretti, V., Gallozzi, S., Jacquemier, J., Khelifi, B., Knödlseder, J., Kocot, J., Kosack, K., Lamanna, G., Lombardi, S., Lucarelli, F., Lyard, E., Maier, G., Massimino, P., Neyroud, N., Osborne, J. P., Perri, M., Reyes, R. De Los, Rico, J., Sanchez, D. A., Satalecka, K., Siejkowski, H., Stolarczyk, T., Szepieniec, T., Testa, V., Walter, R., Ward, J. E., Zoli, A.   +40 more
core   +4 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Archiving scientific blogs with ArchivePress [PDF]

, 2009
A poster describing the ArchivePress blog archiving approach and project, presented at the International Digital Curation Conference, London, December ...
Davis, Richard M., Pennock, Maureen, Pinsent, Edward   +2 more
core  

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

One Schema to Rule them All. The Inner Workings of the Digital Archive ARCHE

Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare, 2018
A Resource Centre for the HumanitiEs (ARCHE) is a digital archive provided by the Austrian Centre for Digital Humanities, which is part of the Austrian Academy of Sciences.
Martina Trognitz, Matej Ďurčo
doaj   +1 more source