Results 91 to 100 of about 1,479 (167)

Effect of esomeprazole on the pharmacokinetics of vepdegestrant, a PROteolysis TArgeting Chimera oestrogen receptor degrader, in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of this study is to evaluate the effects of multiple doses of esomeprazole, a strong proton pump inhibitor and acid‐reducing agent, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera oestrogen receptor degrader.
Lana Tran, Naihan Chen, Jennifer A. Winton, Kyle T. Matschke, Smita P. Goodman, Kimberly C. Lee, Yuanyuan Zhang, Weiwei Tan   +7 more
wiley   +1 more source

Microtopography enhances intestinal drug absorption via Piezo1‐mediated tight junction modulation

BMEMat, EarlyView.
Microtopography‐driven enhancement of oral peptide drug delivery by activating Piezo1 channels significantly improves paracellular permeability and bioavailability, offering a novel approach for optimizing macromolecule absorption in pharmaceutical formulations.
Yu Hu, Nan Xu, Xin Li, Xiaowo Kang, Tieyuan Bian, Junsheng Lin, Hao Tang, Yinyin Bao, Lu Zhang, Hongyan Yuan, Mingxi Yao, Xingyu Jiang, Zhi Luo   +12 more
wiley   +1 more source

Extent, characteristics and policy applications of Key Biodiversity Areas

Biological Reviews, EarlyView.
ABSTRACT A global standard for the identification of Key Biodiversity Areas (KBAs) was published 10 years ago to provide a unified set of criteria for identifying ‘sites of significance for the global persistence of biodiversity’. We review the initiative's origins, the KBA identification process, characteristics of the current network, threats, policy
Stuart H. M. Butchart, Olivia Crowe, Tom Scott, Andrew J. Plumptre, Megan Eldred, Ellen McKee, Zoltan Waliczky, Ibrahim Al Hasani, Adrián B. Azpiroz, Daniele Baisero, Fred Barasa, Alison E. Beresford, Bezeng S. Bezeng, Charlotte Boyd, Thomas M. Brooks, Graeme Buchanan, Gill Bunting, Sofia Capellan, Neil Cox, Tim R. B. Davenport, Tammy E. Davies, Gina Della Togna, Wendy Elliott, Matt Foster, Jo Gilbert, Jonathan M. Handley, Diego Juffe‐Bignoli, Victoria R. Jones, Naomi Kingston, Jeannot Kivono, John Lamoreux, Penny F. Langhammer, James Lewis, Bruce Liggitt, Daniel Marnewick, Paul Matiku, Erin McCreless, Rachel A. Neugarten, Catherine Numa, Mark O'Brien, Madhu Rao, Ciara Raudsepp‐Hearne, Justina C. Ray, Samridhi Rijal, Jon Paul Rodríguez, Jurgis Sapijanskas, Wes Sechrest, Martin Sneary, Andrew Snyder, Konstantina Spiliopoulou, Thomas Starnes, Cecilia Tobar, Gautam Surya, Marcelo F. Tognelli, Andrew W. Tordoff, Maria G. Toscano, Yongyut Trisurat, Amy Upgren   +57 more
wiley   +1 more source

Trade‐offs in avian parental care: a review of theory and meta‐analysis of brood size manipulations

Biological Reviews, EarlyView.
ABSTRACT The selective forces shaping parental care have been studied for over 50 years. While theoretical and experimental work has yielded qualitative progress, the large body of empirical work testing predictions about parental investment based on life‐history trade‐offs has yet to be synthesized.
Rebekah A. McKinnon, Malgorzata Lagisz, Sheeraja Sridharan, David F. Westneat, Kimberley J. Mathot   +4 more
wiley   +1 more source

Venture Funding: Signals of Environmental Orientation and Their Interplay With Investor‐ and Country‐Level Characteristics

Business Strategy and the Environment, EarlyView.
ABSTRACT Environmentally oriented ventures pursue a dual mission: to create both environmental and financial value. This dual mission adds complexity and can influence ventures' funding prospects, as investors mostly pursue financial motivations.
David Flore, Corinna Vera Hedwig Schmidt, Steffen Strese   +2 more
wiley   +1 more source

When Do Robots Go Green? Unveiling Mechanisms, Thresholds, and Spillovers of Industrial Robotics on Global Ecological Capacity

Business Strategy and the Environment, EarlyView.
ABSTRACT This paper examines the relationship between industrial robotics adoption and ecological capacity, measured by biocapacity, using panel data from 50 countries over the period 2000–2024. We investigate the transmission mechanisms, non‐linearities, spatial spillovers, and heterogeneity characterizing this relationship.
Brahim Bergougui, Hamid Ghazi H. Sulimany   +1 more
wiley   +1 more source

Can Carbon Strategy Enhance Corporate Productivity? Evidence From Carbon Risk and Opportunity Management

Business Strategy and the Environment, EarlyView.
ABSTRACT Whether corporate carbon management can enhance productive efficiency is central to firms' long‐term competitiveness and determines whether carbon reduction efforts can be sustained beyond regulatory compliance. This study examines how corporate carbon risk and opportunity management affects firm productivity (measured by total factor ...
Nan Huang, Hanlu Fan, Ruoxin Zhu
wiley   +1 more source

Connecting Thoughts and Actions: A Managerial Process Model on Circular Business Model Innovation

Business Strategy and the Environment, EarlyView.
ABSTRACT Addressing environmental grand challenges such as resource scarcity requires circular business model innovation (CBMI) that enables firms to efficiently close and slow resource cycles through novel activity systems. Drawing on a grounded theory approach based on 59 in‐depth interviews with top managers from Swiss SMEs, we developed a process ...
Fabian Takacs, Karolin Frankenberger
wiley   +1 more source

Green Entrepreneurship Research: A Review of the Domain and Future Research Agenda

Business Strategy and the Environment, EarlyView.
ABSTRACT This study examined the evolving landscape of green entrepreneurship (GE) research through a comprehensive analysis that combined bibliometric and systematic literature reviews. Analysis of 88 articles retrieved from the Web of Science (WoS) mapped the research trajectory, identifying key authors, journals and research themes.
Clavis Nwehfor Fubah, Jonathan Mukiza Kansheba, Mutaju Isaack Marobhe, Gaye Acikdilli   +3 more
wiley   +1 more source

Emission Reduction Targets Between Strategy and Executive Compensation: Evidence on Symbolic and Substantive Adoption From German Listed Firms

Business Strategy and the Environment, EarlyView.
ABSTRACT Firms increasingly commit to climate targets yet doubts remain about whether such pledges translate into substantive corporate governance or remain symbolic. The study examines how emission reduction targets (ERTs) in sustainability strategies are reflected in compensation among German listed firms.
Victoria Fohrer, Anna‐Sofia Grabowski
wiley   +1 more source