Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Alexander disease (AxD) is a severe neurodegenerative disorder caused by gain‐of‐function mutations in the gene for GFAP, which lead to protein aggregation and a primary astrocytopathy. Symptoms vary, but failure to thrive (FTT) and frequent emesis are common and cause significant morbidity. Here we investigate GDF15, a member of the
Tracy L. Hagemann +6 more
wiley +1 more source
2019 State-of-the-Science of Dispersants and Dispersed Oil (DDO) in U.S. Arctic Waters: Public Health and Food Safety [PDF]
, 2019 Chemical dispersants were employed on an unprecedented scale during the Deepwater Horizon oil spill in the Gulf of Mexico, and could be a response option should a large spill occur in Arctic waters. The use of dispersants in response to that spill raised
Coastal Response Research Center
core +2 more sources
SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas +18 more
wiley +1 more source
Results of an Arctic Council survey on water and sanitation services in the Arctic [PDF]
, 2018 Jonathan Bressler, Thomas W. Hennessy
openalex +1 more source
Data Assimilation of AOD and Estimation of Surface Particulate Matters over the Arctic [PDF]
, 2021 Kyung Man Han +12 more
openalex +1 more source
Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan +12 more
wiley +1 more source
A Look at Important Marine Areas in the U.S. Beaufort and Chukchi Seas: Ecologically rich places to protect in the Arctic Ocean [PDF]
, 2016 Sound decision-making about the future of the U.S. Arctic Ocean must include an understanding of how its marine ecosystems function. Although all areas of the U.S. Chukchi and Beaufort seas contribute to ecological integrity, some are especially vital to
core
Arctic shipping: A systematic literature review of comparative studies
, 2018 Dimitrios Theocharis +3 more
openalex +2 more sources
Computer Prediction of Seawater Sensor Parameters in the Central Arctic Region Based on Hybrid Machine Learning Algorithms [PDF]
, 2020 Yuchen Wang +10 more
openalex +1 more source