Results 171 to 180 of about 577,992 (312)

Arctic Sentinels

PLoS Biology, 2008
openaire   +4 more sources

Arctic Geology * [PDF]

Nature, 1875
openaire   +4 more sources

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Strengthening networks in Arctic health research and education through mentorship and collaboration. [PDF]

Int J Circumpolar Health
Ingemann C, Akearok GH, Crawford A, Cueva K, Drossos A, Emelyanova A, Fairman K, Hansen KL, Koch A, Mulvad G, Olesen I, Rautio A, Rink E, Rönkä AR, Stoor JPA, Larsen CV.   +15 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

The Arctic vegetation is more sensitive to heatwave-induced photosynthetic decline than other climate zones in Europe (2009-2017). [PDF]

Sci Rep
Hwang YS, Schlüter S, Park H, Um JS.
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Environmental distribution, physiology and genomic adaptations of arctic ammonia-oxidizing archaea. [PDF]

Front Microbiol
Díez MM, Dreer M, Schleper C, Kerou M.
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

The future of the Arctic flora under climate change. [PDF]

Natl Sci Rev
Zhang J, Peng HW, Ding HT, Chen G, Erst AS, Li JF, Lian L, Xia FC, Zhou X, Spicer RA, Yang J, Wang W.   +11 more
europepmc   +1 more source