Results 131 to 140 of about 4,907 (289)

Physical Characteristics of Arctic Fox (Alopex Lagopus) Dens in Svalbard

, 1992
Physical characteristics of 73 arctic fox (Alopex lagopus) dens in Svalbard are described. In a mountainous study area of 975 sq/km, most dens were found below 200 m and none was found above 400 m. Most dens were located in slopes in valleys or along the
Prestrud, Päl
core  

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Arctic fox (Alopex lagopus) diet in Karupelv valley, East Greenland, during a summer with low lemming density

, 2000
We investigated the diet of arctic foxes (Alopex lagopus) in the Karupelv valley, East Greenland, during the summer of 1997. Despite a low density, lemmings were the most utilized prey, comprising 65.3% of dry fecal weight in fresh feces.
Angerbjörn, Anders,, Dalerum, Fredrik,
core  

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

Advanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li, Xiuling Zhi, Qianhan Lin, Yating Sun, Yihua Sun, Zulimire Abudousalamu, Mengyang Xue, Chang Zheng, Xiaotian Li, Liangqing Yao, Mo Chen   +10 more
wiley   +1 more source

Orthogonal Ionic Liquid‐Based Extraction Strategy Enables Amyloid‐Specific Profiling of Aggregate Proteome

Advanced Science, EarlyView.
An orthogonal ionic‐liquid extraction (Orth‐iEA) enables selective isolation of amyloid fibrils. TMGBF4 disrupts hydrogen‐bonded β‐sheet networks to solubilize amyloid aggregates, whereas C12ImCl interacts with hydrophobic regions of non‐amyloid proteins.
Shiying Zheng, Ye Liu, Bowen Zhong, Huiying Chu, Zhou Gong, Baofeng Zhao, Mengchun Cheng, Zhen Liang, Yukui Zhang, Qun Zhao, Lihua Zhang   +10 more
wiley   +1 more source

Emergent rainy winter warm spells may promote boreal predator expansion into the arctic

, 2016
Climate change has been characterized as the most serious threat to Arctic biodiversity. In addition to gradual changes such as climate warming, extreme weather events, such as melting temperatures in winter and rain on snow, can have profound ...
Sokolova, Natalya A., Ehrich, Dorothee, Sokolov, Aleksandr A., Brucker, Ludovic, Ims, Rolf A., Ims, Rolf Anker   +5 more
core   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

Investigating the impact of helminths on mercury in Arctic foxes

Mercury (Hg) pollution in the Arctic poses a growing threat to the health of local wildlife, yet many factors behind Hg bioaccumulation remain poorly understood.
Whiteside, Kayla
core  

Intra‐population variation in the effects of sea ice reduction on an Arctic breeding bird

Ecosphere
The Arctic is warming four times faster than any other region on Earth, leading to a dramatic reduction in sea ice. Even though sea ice plays a key role in the ecology of many Arctic species, few studies have assessed the consequences of its ...
Hilde Dørum, Sébastien Descamps, Børge Moe, Bård‐Jørgen Bårdsen, Kjell Tore Hansen, Sveinn Are Hanssen, Christophe Sauser, Marika Marnela, Sebastian Gerland, Geir W. Gabrielsen   +9 more
doaj   +1 more source

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, EarlyView.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source