Results 141 to 150 of about 4,907 (289)

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

open access: yesAdvanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin   +16 more
wiley   +1 more source

Does the red fox threatens the existence of the Swedish arctic fox? [PDF]

open access: yes, 2016
Fjällräven (Vulpes lagopus) har sedan 30-talet varit hotad i Skandinavien och trots att den varit skydda mot jakt så har den inte återhämtat sig. Då jakt inte har varit ett hot mot den svenska fjällräven de senaste 80 åren finns det andra teorier om ...
Dadell, Linn
core  

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

open access: yesAdvanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li   +13 more
wiley   +1 more source

Shifts in Fox Den Occupancy in the Greater Prudhoe Bay Area, Alaska

open access: yes, 2014
Although shifts in the distribution of red foxes into areas previously dominated by Arctic foxes have been documented over wide areas of the circumpolar North, no such documentation exists yet for the Alaskan Arctic.
Stickney, Alice A.   +2 more
core  

Prioritisation of areas for early detection of southward movement of arctic fox rabies based on historical surveillance data in Quebec, Canada. [PDF]

open access: yesEpidemiol Infect, 2020
Aenishaenslin C   +7 more
europepmc   +1 more source

Microbial Odorant Detection Guides Drosophila Parasitoids Seeking Hosts in Fermenting Fruits

open access: yesAdvanced Science, EarlyView.
Yeast microbes in fermenting fruits attract both host flies and their parasitoid wasps. Female Leptopilina boulardi detect yeast‐emitted ethyl esters via two olfactory receptors, LbouOR167 and LbouOR136. A conserved residue, Leu159, is critical for binding these compounds, enabling female wasps to locate host‐rich habitats.
Yueqi Lu   +11 more
wiley   +1 more source

Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy

open access: yesAdvanced Science, EarlyView.
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen   +8 more
wiley   +1 more source

Efficiency of Winter Scavengers in the Arctic

open access: yes, 1972
Frozen carcasses of brown lemmings, Lemmus trimucronatus, were systematically placed under the snow in various tundra habitats in the fall of 1961 (188), 1962 (201) and 1963 (205) near Barrow, Alaska.
Pitelka, Frank A., Mullen, David A.
core  

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