Results 51 to 60 of about 61,906 (291)

Predation of endangered Arctic foxes by Golden eagles: What do we know?

Ecology and Evolution, 2023
Dedicated conservation efforts spanning the past two decades have saved the Fennoscandian Arctic fox (Vulpes lagopus) population from local extinction, and extensive resources continue to be invested in the species' conservation and management.
Craig R. Jackson, Lars Rød‐Eriksen, Jenny Mattisson, Øystein Flagstad, Arild Landa, Andrea L. Miller, Nina E. Eide, Kristine Roaldsnes Ulvund   +7 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Harmonizing circumpolar monitoring of Arctic fox: benefits, opportunities, challenges and recommendations

Polar Research, 2017
The biodiversity working group of the Arctic Council has developed pan-Arctic biodiversity monitoring plans to improve our ability to detect, understand and report on long-term change in Arctic biodiversity. The Arctic fox (Vulpes lagopus) was identified
Dominique Berteaux, Anne-Mathilde Thierry, Ray Alisauskas, Anders Angerbjörn, Eric Buchel, Liliya Doronina, Dorothee Ehrich, Nina E. Eide, Rasmus Erlandsson, Øystein Flagstad, Eva Fuglei, Olivier Gilg, Mikhail Goltsman, Heikki Henttonen, Rolf A. Ims, Siw T. Killengreen, Alexander Kondratyev, Elena Kruchenkova, Helmut Kruckenberg, Olga Kulikova, Arild Landa, Johannes Lang, Irina Menyushina, Julia Mikhnevich, Jukka Niemimaa, Karin Norén, Tuomo Ollila, Nikita Ovsyanikov, Liya Pokrovskaya, Ivan Pokrovsky, Anna Rodnikova, James D. Roth, Brigitte Sabard, Gustaf Samelius, Niels M. Schmidt, Benoit Sittler, Aleksandr A. Sokolov, Natalya A. Sokolova, Alice Stickney, Ester Rut Unnsteinsdóttir, Paula A. White   +40 more
doaj   +1 more source

Sequencing of rabies binding region on nicotinic acteylcholine receptor alpha subunits in four host species [PDF]

, 2013
• Rabies virus is known to bind to nicotinic acetylcholine receptors (nAchR) • The virus is known to bind to alpha 1 subunits nAchR • The virus binding region has been characterized in alpha 1 subunits of these receptors • Little research has been ...
Barnard, Karen
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Studies of the Helminth Fauna of Norway XXXIV: The morphological stability of Diphyllobothrium Cobbold. A comparison of adult D. dendriticum (Nitzsch), D. latum (L.) and D. ditremum (Creplin) developed in different hosts [PDF]

, 1975
Adult D. dendriticum from common gull {Larus canus), herring gull (Larus argentatus) and arctic fox (Alopex lagopus), D. latum from arctic fox, and D. ditremum from merganser (Mergus merganser) were studied.
Andersen, Karin
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Canine-Derived Cosmid Probes Containing Microsatellites Can Be Used in Physical Mapping of Arctic Fox (Alopex lagopus) and Chinese Raccoon Dog (Nyctereutes procyonoides procyonoides) Genomes [PDF]

, 2017
Rapid development of the canine marker genome map facilitates genome mapping of other Canidae species. In this study we present chromosomal localization of 18 canine-derived cosmid probes containing microsatellites in the arctic fox (Alopex lagopus) and ...
Dolf, G., Rogalska-Niznik, N., Schelling, C., Schläpfer, J., Switonski, M., Szczerbal, I.   +5 more
core  

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source