Results 151 to 160 of about 43,979 (259)

Cathepsin K Aggravates Pulmonary Fibrosis Through Promoting Fibroblast Glutamine Metabolism and Collagen Synthesis

Advanced Science, EarlyView.
CTSK plays a critical role in pulmonary fibrosis. Excessive CTSK accumulation interacts with SNX9 to enhance TGF‐β1‐induced SMAD3 activation and GLS1 expression in fibroblasts, driving glutamine metabolism for collagen biosynthesis and exacerbating pulmonary fibrosis.
Mengting Chen, Xiaoxiao Meng, Yong Zhu, Dapeng Wang, Mengmeng Wang, Ziyuan Wang, Xue Tian, Jiaxiang Zhang, Zhiying Yue, Zhengfeng Yang, Ruilan Wang   +10 more
wiley   +1 more source

Complex Origins and History of the Relict Fennoscandian Ringed Seals. [PDF]

Ecol Evol
Tange Olsen M, Löytynoja A, Valtonen M, Knudsen SW, Bang S, Gunnersen C, Rosing-Asvid A, Ferguson SH, Dietz R, Kovacs KM, Lydersen C, Jernvall J, Auvinen P, Galatius A.   +13 more
europepmc   +1 more source

Targeting Cystine Metabolism in the Lung Cancer Environment Enhances the Efficacy of Immune Checkpoint Inhibition

Advanced Science, EarlyView.
The tumor‐associated macrophages (TAMs) in lung cancer tissues exhibit active cystine metabolism. Restricting cystine concentration in macrophages induces M1 phenotypic polarization and upregulation of PD‐L1 expression through the GSH‐NF‐κB signaling pathway.
Yun Xu, Shumin Li, Jiaji Wu, Shumin Xu, Mo Shen, Chenyang Wang, Lundqvist Andreas, Jianghao Yu, Zhiyong Xu, Yueli Shi, Nana Liu, Yunke Yang, Jiangnan Zhao, Ying Yang, Pingli Wang, Peng Yi, Jin Cheng, Junhui Sun, Mengshu Li, Peng Xiao, Kai Wang   +20 more
wiley   +1 more source

Shotgun metagenomics reveals the flexibility and diversity of Arctic marine microbiomes. [PDF]

ISME Commun
Freyria NJ, de Oliveira TC, Meng A, Pelletier E, Lovejoy C.   +4 more
europepmc   +1 more source

Tumor‐Associated Sympathetic Nerves Promote the Progression of Epstein‐Barr Virus‐Positive Diffuse Large B‐Cell Lymphoma

Advanced Science, EarlyView.
Sympathetic nerve innervation promotes the progression of Epstein‐Barr virus‐positive diffuse large B‐cell lymphoma (EBV+ DLBCL) via β2‐adrenergic receptors. The discovery of enhanced nerve infiltration and β2AR expression reveals a novel mechanism and highlights the sympathetic–β2AR axis as a promising target for therapeutic intervention in EBV+ DLBCL.
Silan Huang, Dexin Lei, Linbin Yang, Aiwei Bi, Yanlou Wang, Peng Zhang, Dongyu Zhuang, Honglian Liu, Qingqing Cai, Man Nie, Yi Xia   +10 more
wiley   +1 more source

Concluding remarks: Atmospheric chemistry in cold environments.

Faraday Discuss
Ammann M.
europepmc   +1 more source

Impacts of Antarctic summer sea-ice extremes. [PDF]

PNAS Nexus
Doddridge EW, Hobbs WR, Auger M, Boyd PW, Chua SMT, Cook S, Corney S, Emmerson L, Fraser AD, Heil P, Kelly N, Lannuzel D, Li X, Liniger G, Massom RA, Meyer A, Reid P, Southwell C, Spence P, Steketee A, Swadling KM, Teder N, Wienecke B, Wongpan P, Yamazaki K.   +24 more
europepmc   +1 more source

The LDH‐H3K18La‐Nur77 Axis Potentiates Immune Escape in Small Cell Lung Cancer

Advanced Science, EarlyView.
Lactate from SCLC tumors induces H3K18 lactylation in naïve CD8+ T cells, upregulating Nurr77 and enhancing tonic TCR signaling. This leads to T cell hyporesponsiveness to stimulation, impairing antitumor immunity and reducing immunotherapy efficacy.
Xiaoling Shang, Bo Cheng, Chenyue Zhang, Chenglong Zhao, Ruiqing Wang, Xun Zhang, Dizhi Jiang, Xinyu Zhang, Xinyue Ma, Hongyuan Mao, Zerun Li, Chenhan Huang, Tianzi Wang, Kaiyue Guo, Liwen Wang, Ning Tang, Haiyong Wang   +16 more
wiley   +1 more source

Physical Drivers of a Massive Harmful Algal Bloom in the Northern Bering and Chukchi Seas in Summer 2022. [PDF]

J Geophys Res Oceans
Lago LS, Pickart RS, Lin P, Bahr F, Fachon E, Brosnahan ML, Pathare M, Muhlbach E, Horn K, Rajagopalan A, Anderson DM.   +10 more
europepmc   +1 more source

Enhanced Media Optimize Bovine Myogenesis in 2D and 3D Models for Cultivated Meat Applications

Advanced Science, EarlyView.
This study uses multiomics approaches to characterize bovine myogenesis in vitro, identifying media components that enhance myogenic progenitor cell differentiation in 2D and 3D models. Notably, the enhanced conditions promoted formation of unique cell populations and contractile muscle cells expressing mature myogenic markers.
Christine L. Trautmann, Adhideb Ghosh, Ali Kerem Kalkan, Falko Noé, Ori Bar‐Nur   +4 more
wiley   +1 more source