Results 161 to 170 of about 726,424 (281)

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Nitrogen fixation under declining Arctic sea ice. [PDF]

Commun Earth Environ
von Friesen LW, Farnelid H, von Appen WJ, Benavides M, Grosso O, Laber CP, Schüttler J, Sundbom M, Torres-Valdés S, Bertilsson S, Peeken I, Snoeijs-Leijonmalm P, Riemann L.   +12 more
europepmc   +1 more source

Transfer of ice algae carbon to ice-associated amphipods in the high-Arctic pack ice environment [PDF]

Journal of Plankton Research, 2017
Thomas A. Brown, Philipp Assmy, Haakon Hop, Anette Wold, Simon T. Belt   +4 more
openaire   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Population Genomic Structure and Demographic History of Black Guillemots Breeding Across the North Atlantic. [PDF]

Ecol Evol
Harkness BAS, Colston-Nepali L, Robertson GJ, Provencher JF, Boccia CK, Friesen VL.   +5 more
europepmc   +1 more source

A pilot experiment to measure arctic pack-ice driving forces

, 1988
Pack-ice driving forces are synonymous with the limiting forces that can be transmitted through pack ice. Knowledge of this topic is important in relation to: ice loads on structures (the limiting driving force approach); ice motion modelling and forecasting; arctic ship routing.
Croasdale, K. R., Comfort, G., Frederking, R. M. W., Graham, B. W., Lewis, E. L.   +4 more
openaire   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Analysis of pack ice deterioration due to wave action on the Grand Banks, Spring 2017

, 2019
The deterioration of pack ice due to wave action on the Grand Banks, offshore Newfoundland, is investigated. A description of wave effects on pack ice is provided that is based on the observations of one of the authors (JB) during several icebreaking ...
Watson, David, Broderick, John, Sayed, Mohamed, Browne, Thomas   +3 more
core  

Narwhals document atlantification of East Greenland. [PDF]

Sci Adv
Heide-Jørgensen MP, Chambault P, Sørensen H, Andresen CS, Ditlevsen S, Sun Q.   +5 more
europepmc   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source