Results 91 to 100 of about 2,287,088 (335)

2018 State-of the Science of Dispersants and Dispersed Oil (DDO) in U.S. Arctic Waters: Eco-Toxicity and Sublethal Impacts [PDF]

open access: yes, 2018
Chemical dispersants were employed on an unprecedented scale during the Deepwater Horizon oil spill in the Gulf of Mexico, and could be a response option should a large spill occur in Arctic waters. The use of dispersants in response to that spill raised
Coastal Response Research Center (CRRC)
core   +1 more source

O MEDICINES IN THE ARCTIC DISTRICTS OF THE SAKHA REPUBLIC (YAKUTIA)

open access: yesСевер и рынок: формирование экономического порядка, 2023
Access to medicines is intrinsically linked to fundamental human rights to health and life. The need to make medicines more accessible is articulated in strategic planning documents, including the Strategy for the Development of the Arctic Zone of the Russian Federation and National Security until 2035.
Sardana M. Tarabukina   +1 more
openaire   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Secular trends and correlates of physical activity: The Tromsø Study 1979-2008

open access: yesBMC Public Health, 2016
Background The aim was to describe secular trends in leisure time physical activity (LTPA) and work related physical activity (WPA) from 1979 to 2008.
Bente Morseth   +4 more
doaj   +1 more source

European Arctic Initiatives Compendium [PDF]

open access: yes, 2014
Julkaistu ...
Dahlbäck, Björn   +3 more
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

MP 2008-02 [PDF]

open access: yes, 2008
This publication is compiled from a three-part series of articles on muskox research in Agroborealis 38.2, 39.1, and 39 ...
Helfferich, Deirdre
core  

Nickel, Cu, Fe, Zn, and Se Accumulation, and the Antioxidant Status of Mushrooms Grown in the Arctic Under Ni/Cu Pollution and in Unpolluted Areas

open access: yesStresses
Mushrooms play an important role in ecosystem sustainability and are highly valued in medicine and human nutrition. Using AAS and biochemical methods of analysis, the antioxidant status and mineral composition of seven mushroom species (Armillaria mellea,
N. Golubkina   +8 more
semanticscholar   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

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