Results 71 to 80 of about 63,512 (302)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Associations between body height and cardiovascular risk factors in women and men: a population-based longitudinal study based on The Tromsø Study 1979–2016

BMJ Open
Objectives Investigate associations between body height and cardiovascular disease risk factors at several time points in women and men across educational levels in Norway.Design Population-based longitudinal study.Setting The Tromsø Study, a population ...
Kristin Benjaminsen Borch, Tom Wilsgaard, Inger Njølstad, Anne Helen Hansen, Sondre Haakonson Arntsen   +4 more
doaj   +1 more source

Differential expression of the miR-17-92 cluster and miR-17 family in breast cancer according to tumor type; results from the Norwegian Women and Cancer (NOWAC) study

Journal of Translational Medicine, 2019
Background MicroRNAs (miRNAs) are promising biomarkers due to their structural stability and distinct expression profile in various cancers. We wanted to explore the miRNA expression in benign breast tissue and breast cancer subgroups in the Norwegian ...
Line Moi, Tonje Braaten, Khalid Al-Shibli, Eiliv Lund, Lill-Tove Rasmussen Busund   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Healthy ecosystems for human and animal health : Science diplomacy for responsible development in the Arctic [PDF]

, 2021
Climate warming is occurring most rapidly in the Arctic, which is both a sentinel and a driver of further global change. Ecosystems and human societies are already affected by warming.
Pshenichnaya, N.,, Nilsson, Lena Maria, Bylund, Helena, Kalantari, Zahra,, Menshakova, M.,, Nilsson, L. M., Sjöstedt, A. (A.), Sjostedt, A.,, Nilsson, Lena Maria,, Leibovici, D. (D.), Nilsson, L.M., Albihn, A. (A.), Rydén, P., Evengård, Birgitta, Nilsson, L. M.,, Albihn, A., Omazic, A., Bylund, H., Mulvad, G.,, Albihn, A.,, Sjöstedt, A., Mulvad, G., Nilsson, L. M. (L. M.), Koch, A.,, Björkman, C., Rydén, P. (P.), Rydén, Patrik,, Jenkins, E. (E.), Thierfelder, T.,, Jenkins, E., Omazic, A.,, Revich, B., Tokarevich, N., Omazic, A. (A.), Evengård, B., Björkman, Christer, Kukarenko, N.,, Rautio, A.,, Menshakova, M. (M.), Jenkins, E.,, Destouni, G., Quegan, S. (S.), Orlov, D., Thierfelder, Tomas, Orlov, D. (D.), Ryden, P.,, Menshakova, M., Björkman, C.,, Lemmityinen, J. (J.), Orlov, D.,, Sjöstedt, Anders, Quegan, S.,, Leibovici, D.,, Rautio, A., Revich, B.,, Kalantari, Z., Thierfelder, T., Destouni, G.,, Bylund, H.,, Revich, B. (B.), Tokarevich, N. (N.), Thierfelder, T. (T.), Koch, A., Leibovici, D., Pshenichnaya, N., Destouni, G. (G.), Quegan, S., Evengård, B. (B.), Koch, A. (A.), Pshenichnaya, N. (N.), Björkman, C. (C.), Tokarevich, N.,, Kukarenko, N., Evengård, Birgitta,, Rautio, A. (A.), Lemmityinen, J.,, Kalantari, Z. (Z.), Kalantari, Z.,, Rydén, Patrik, Lemmityinen, J., Destouni, Georgia,, Kukarenko, N. (N.), Bylund, H. (H.), Evengard, B.,, Sjöstedt, Anders,, Mulvad, G. (G.)   +85 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

SARS-CoV-2 infection during pregnancy and the risk of adverse maternal outcomes in the Republic of Georgia: a national birth registry-based cohort study

BMC Pregnancy and Childbirth
Background Georgia experienced an increase in maternal deaths (MD) during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, which warrants further investigation.
Natia Skhvitaridze, Amiran Gamkrelidze, Tinatin Manjavidze, Tormod Brenn, Charlotta Rylander   +4 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source