Results 61 to 70 of about 63,512 (302)

瑞典于默奥大学（Umeå University）北极中心：通过战略网络促进和支持北极研究 [Elektronisk resurs] : [Arctic Centre at Umeå University, Sweden: promoting and supporting Arctic research through strategic networking]

, 2022
When established in 2012, the Arctic Centre of Umeå University (Arcum) became the first cohesive center for Arctic research in Sweden. Since then, strategic networking on all levels has grown.
Eklund, Niklas,, Nilsson, Lena Maria,
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Anthropometric measures are satisfactory substitutes for the DXA‐derived visceral adipose tissue in the association with cardiometabolic risk—The Tromsø Study 2015–2016

Obesity Science & Practice, 2021
Background Body mass index (BMI) increases while cardiometabolic risk factors decrease in individuals in high‐income countries. This paradoxical observation raises the question of whether current measures of overweight and obesity properly identify ...
Marie W. Lundblad, Bjarne K. Jacobsen, Jonas Johansson, Sameline Grimsgaard, Lene F. Andersen, Laila A. Hopstock   +5 more
doaj   +1 more source

Lifestyle factors as mediators of area-level socio-economic differentials in cardiovascular disease risk factors. The Tromsø Study

SSM: Population Health, 2022
Introduction: Cardiovascular disease (CVD) is a leading cause of death and disability and living in areas with low socio-economic status (SES) is associated with increased risk of CVD.
Sweta Tiwari, Ester Cerin, Tom Wilsgaard, Ola Løvsletten, Inger Njølstad, Sameline Grimsgaard, Laila A. Hopstock, Henrik Schirmer, Annika Rosengren, Kathrine Kristoffersen, Maja-Lisa Løchen   +10 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Secular trends and correlates of physical activity: The Tromsø Study 1979-2008

BMC Public Health, 2016
Background The aim was to describe secular trends in leisure time physical activity (LTPA) and work related physical activity (WPA) from 1979 to 2008.
Bente Morseth, Bjarne K. Jacobsen, Nina Emaus, Tom Wilsgaard, Lone Jørgensen   +4 more
doaj   +1 more source

Overall lifestyle changes in adulthood are associated with cancer incidence in the Norwegian Women and Cancer Study (NOWAC) – a prospective cohort study

BMC Public Health, 2023
Background Cancer is a leading cause of premature death worldwide and incidence is expected to rise in the coming decades. Many cohort studies, measuring lifestyle factors at one time-point, have observed that overall healthy lifestyles were inversely ...
Sairah L. F. Chen, Therese H. Nøst, Edoardo Botteri, Pietro Ferrari, Tonje Braaten, Torkjel M. Sandanger, Kristin B. Borch   +6 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Mechanisms of accidental fall injuries and involved injury factors: a registry-based study

Injury Epidemiology, 2020
Background Falls are the leading cause of injury-related morbidity and mortality worldwide, but fall injury circumstances differ by age. We studied the circumstances of accidental fall injuries by age in Shenkursk District, Northwest Russia, using the ...
Tatiana Nikolaevna Unguryanu, Andrej Mechislavovich Grjibovski, Tordis Agnete Trovik, Børge Ytterstad, Alexander Valerievich Kudryavtsev   +4 more
doaj   +1 more source