Results 101 to 110 of about 2,287,088 (335)

Associations between body height and cardiovascular risk factors in women and men: a population-based longitudinal study based on The Tromsø Study 1979–2016

BMJ Open
Objectives Investigate associations between body height and cardiovascular disease risk factors at several time points in women and men across educational levels in Norway.Design Population-based longitudinal study.Setting The Tromsø Study, a population ...
Kristin Benjaminsen Borch, Tom Wilsgaard, Inger Njølstad, Anne Helen Hansen, Sondre Haakonson Arntsen   +4 more
doaj   +1 more source

Differential expression of the miR-17-92 cluster and miR-17 family in breast cancer according to tumor type; results from the Norwegian Women and Cancer (NOWAC) study

Journal of Translational Medicine, 2019
Background MicroRNAs (miRNAs) are promising biomarkers due to their structural stability and distinct expression profile in various cancers. We wanted to explore the miRNA expression in benign breast tissue and breast cancer subgroups in the Norwegian ...
Line Moi, Tonje Braaten, Khalid Al-Shibli, Eiliv Lund, Lill-Tove Rasmussen Busund   +4 more
doaj   +1 more source

Radionuclides in arctic marine macroalgae from Kongsfjorden (Svalbard) [PDF]

, 2018
Seaweeds are known to be useful environmental bioindicators since they bioaccumulate radioisotopes at very low environmental concentrations. Levels of natural radionuclides in six ecologically relevant brown and red seaweed species from Arctic coasts ...
Carmona-Fernandez, Raquel, Cañete -Hidalgo, Sergio, Dueñas-Buey, Mª Concepción, Gordo, Elisa, Liger-Pérez, Esperanza, López-Gordillo, Francisco Javier, Pastor-Vega, Jose Manuel, Perez-Martinez, Manuel, Ruiz-Cruces, Rafael   +8 more
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Triggers, Protectors, and Predictors in Episodic Migraine. [PDF]

, 2018
PURPOSE OF REVIEW: A wide variety of triggers prompt attacks in episodic migraine. Although experimental triggers such as glyceryl trinitrate reliably produce migraine, natural triggers are much less predictable and vary in importance between individuals.
Marmura, Michael J.
core   +1 more source

Real-world retrospective cohort study ARCTIC shows burden of comorbidities in Swedish COPD versus non-COPD patients

npj Primary Care Respiratory Medicine, 2018
This study aimed to generate real-world evidence to assess the burden of comorbidities in COPD patients, to effectively manage these patients and optimize the associated healthcare resource allocation.
B. Ställberg, C. Janson, K. Larsson, G. Johansson, K. Kostikas, J. gruenberger, F. Gutzwiller, L. Jørgensen, M. Uhde, K. Lisspers   +9 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Geochemical analysis of Cenozoic fossil conifers at high latitudes: Implications for molecular preservation and environmental change [PDF]

, 2010
Fossil materials record ancient life and their adapted environment. Arctic plant fossils are critical for our understanding of the Earth’s paleoenvironment when high latitudes were under ice-free conditions.
Witkowski, Caitlyn
core   +1 more source

Clinical Assessment of Injuries Inflicted with the Use of Firearms of Limited Destruction to Residents of the Arctic Zone of the Arkhangelsk region, 2006–2022

Disaster Medicine
Summary. The purpose of the study is to provide a clinical description of injuries inflicted with the use of firearms of limited destruction (LDL) to residents of the Arctic zone of the Arkhangelsk region (Arctic zone). Materials and methods of research.
S. Yasheva, Y. Barachevskiy, A.V. Baranov, V.V. Maslyakov, E. Mordovskiy, S.G. Kuzin   +5 more
semanticscholar   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source