Results 81 to 90 of about 933 (190)
British Journal of Clinical Pharmacology, EarlyView.Introduction In recent years, the treatment of spinal muscular atrophy (SMA), a rare disease, has significantly progressed, improving patients' survival and overall quality of life. However, current SMA treatments are expensive, and some (nusinersen) are very inconvenient for patients.
Andrej Belančić +4 more
wiley +1 more source
Efficacy, safety and cost‐effectiveness of CAR‐T therapy
British Journal of Clinical Pharmacology, EarlyView.CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher +7 more
wiley +1 more source
Frontiers in Environmental ScienceThe effects of global climate change have accelerated the melting of glaciers and the decline of sea ice coverage in the Arctic. In tandem with advancements in icebreaker and other shipping technologies, the navigability of Arctic shipping routes has ...
Huirong Liu, Zhengkai Mao, Zhijun Zhang
doaj +1 more source
Biological Reviews, EarlyView.ABSTRACT Effective knowledge of ecological connectivity at sea and at the land–sea interface is key to supporting global policy goals to conserve and restore ocean biodiversity and function. However, a persistent lack of commonality in terminology and understanding around the concept of connectivity in marine ecological studies hampers its integration ...
Audrey M. Darnaude +20 more
wiley +1 more source
Russia and America in the 21st CenturyIn 2015, Ankara applied to participate in the work of the Arctic Council as an observer state and was expectedly rejected. The article is devoted to the main directions of Turkey's Arctic policy, as well as the main problems of its implementation.
openaire +1 more source
The impacts of biological invasions
Biological Reviews, EarlyView.ABSTRACT The Anthropocene is characterised by a continuous human‐mediated reshuffling of the distributions of species globally. Both intentional and unintentional introductions have resulted in numerous species being translocated beyond their native ranges, often leading to their establishment and subsequent spread – a process referred to as biological
Phillip J. Haubrock +42 more
wiley +1 more source
China’s policy in the Arctic: ambitions and realities
RUDN Journal of World HistoryThe relevance of the research topic is due to the increasing interest of the PRC in Arctic issues. Despite the fact that China is not one of the Arctic and sub-Arctic states, it plays an active role among non-Arctic players in the issue of ...
Anastasia A. Zabella
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CHINA’S NEW ARCTIC POLICY (On the White Paper “China’s Arctic Policy”) [PDF]
World Economy and International Relations, 2019 Zengjun KUANG, Kaifei OU
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Framing Modern Slavery: Do Stakeholders Talk Past Each Other?
Canadian Journal of Administrative Sciences / Revue Canadienne des Sciences de l'Administration, EarlyView.ABSTRACT Modern slavery literature has thus far mostly adopted a downstream perspective, in the sense that researchers investigated corporate actors' responses after the enactment of transparency legislation. The common finding is that corporate disclosure is poor and ineffective, contributing to a failure to eradicate modern slavery.
Sylvain Durocher +2 more
wiley +1 more source