Results 111 to 120 of about 232,498 (309)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Professional Self-Determination of Schoolchildren in Years 8–10 of Arctic and Russian Far East Regions: Sociological Analysis

Социологическая наука и социальная практика, 2019
The article deals with the features of professional self-determination of schoolchildren in years 8–10 of Arctic and Russian Far East regions. The study revealed factors that influence the choice of future professions by schoolchildren; generalized ...
Anna V. Simakova
doaj   +1 more source

Prevalence of the polymorphic H-f icolin (FCN3) genes and mannose-binding lectin-associated serine protease-2 (MASP2) in indigenous populations from the Russian Arctic regions. [PDF]

Vavilovskii Zhurnal Genet Selektsii, 2021
Smolnikova MV, Tereshchenko SY.
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

A METHODOLOGICAL FRAMEWORK FOR IDENTIFYING EMPLOYMENT GROWTH DRIVERS IN THE ARCTIC ECONOMY

Север и рынок: формирование экономического порядка
Developing an effective employment system in the Arctic regions in the context of stagnant demographic and migration trends requires identifying types of economic activities that significantly influence employment growth.
Vladimir Nikolaevich Myakshin
doaj   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Tropospheric ozone and aerosols measured by airborne lidar during the 1988 Arctic boundary layer experiment [PDF]

Ozone (O3) and aerosol distributions were measured from an aircraft using a differential absorption lidar (DIAL) system as part of the 1988 NASA Global Tropospheric Experiment - Arctic Boundary Layer Experiment (ABLE-3A) to study the sources and sinks of
Browell, Edward V., Butler, Carolyn F., Kooi, Susan A.   +2 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

RUSSIAN ARCTIC REGIONS: MACROECONOMIC TRENDS, ENVIRONMENTAL AND ECONOMIC RESILIENCE

Север и рынок: формирование экономического порядка
This paper explores the environmental and economic resilience of the regions within the Arctic zone of the Russian Federation (AZRF). We define a region’s environmental and economic resilience as its capacity to withstand external shocks, independently ...
Nadezhda A. Krasilnikova, Anna S. Lukovtseva, Erkhan E. Savvin   +2 more
doaj   +1 more source

Mining in Arctic and Non-Arctic Regions: A Socioeconomic Assessment [PDF]

, 2016
In this paper, we study how mines change local societies in the Nordic countries with a particular focus on the Arctic region. Our study is based on register data at the municipality level from Norway, Sweden, and Finland for the period 1986 to 2013. The
Frederiksen, Anders, Kadenic, Maja Due
core