Results 91 to 100 of about 50,296 (313)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Royal E. Shanks [PDF]

open access: yes, 1963
Royal E. Shanks was born in Ada, Ohio on November 11, 1912. He lost his life on August 4, 1962 while swimming and studying a coral reef in a bay of the Caribbean Sea in Porte Limon, Costa Rica. He completed his M. S. in 1937 and received his Ph.D. degree
North America, Arctic Institute of
core   +1 more source

THE RADIO WAVES PROPAGATION CHARACTERISTICS IN THE GLIDESLOPE AXES OF THE GROUND CONTROLLED APPROACH SYSTEMS IN THE ARCTIC REGIONS

open access: yesНаучный вестник МГТУ ГА, 2016
Information about the location of the aircraft, with a decrease along a predetermined path, the carriages, the floor-fer with the use of radio landing systems.
G. S. Nakhmanson   +2 more
doaj  

Masters Students' Perceptions of Distance and Transport Options

open access: yesEducation in the North, 2018
This article is situated within the Arctic Regions North Norway and North/East Iceland. It presents a study on what motivates adults in Arctic regions to apply for and complete a Master’s degree in Education.
Mirjam Harkestad Olsen   +1 more
doaj   +1 more source

Seasonal variations in physical activity among Norwegian elementary school children in Arctic regions. [PDF]

open access: yesInt J Circumpolar Health, 2021
Danielsen KH   +4 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

Incidence of socially significant infectious diseases (HIV, TB and HIV/TB coinfection) in the Arctic regions of Russia). [PDF]

open access: yesInt J Circumpolar Health, 2021
Zagdyn Z   +6 more
europepmc   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Commentary: Arctic Research in Russia [PDF]

open access: yes, 1993
The Russian Republic has an arctic zone of 2.5 million sq. km, including vast territories to the north of the Arctic Circle, the seas of the Arctic Ocean and many archipelagoes.
Pavlenko, Vladimir
core   +1 more source

DIGITALIZATION AS A TOOL FOR MANAGING INNOVATION-DRIVEN SUSTAINABLE DEVELOPMENT IN THE ARCTIC INDUSTRIAL SECTOR

open access: yesСевер и рынок: формирование экономического порядка
The sustainable development of industrial production is particularly critical in the Arctic regions. However, achieving this goal requires effective management, which can be improved through digitalization based on algorithmic processes.
Vladimir S. Zharov
doaj   +1 more source

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