Results 81 to 90 of about 50,296 (313)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
A model study Of chemistry and transport in the Arctic troposphere [PDF]
, 2011 In this thesis the TOMCAT chemical transport model is used to investigate the processes which control the concentrations of CO and O3 in the Arctic troposphere. Particular focus is on understanding the main sources of CO, O3 and NOy species in the Arctic,
Monks, Sarah Anne
core
Re-evaluating the list of high-production chemicals predicted to become Arctic contaminants [PDF]
, 2010 The large number of historical and current organic chemicals in commerce, and the ability of these compounds to make their way from industrial to remote regions, has resulted in concerted efforts to predict which chemicals have the capacity to migrate ...
Sierra Rayne, Kaya Forest
core +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Interactions between arctic and red foxes in Scandinavia - predation and aggression. Arctic [PDF]
, 1989 . Arctic fox (Alopex lagopus) populations in Scandinavia are small and restricted to alpine regions, while red foxes (Vulpes vulpes) are common throughout both Norway and Sweden.
Angerbjörn, Anders +5 more
core +1 more source
Impact of Variable Atmospheric and Oceanic Form Drag on Simulations of Arctic Sea Ice [PDF]
, 2014 Over Arctic sea ice, pressure ridges and floe and melt pond edges all introduce discrete obstructions to the flow of air or water past the ice and are a source of form drag.
Laxon, Seymour W. +11 more
core +1 more source
Север и рынок: формирование экономического порядкаUnder financial constraints, the formulation of structural and investment policies in the Arctic regions must account for investment flows between industries. This highlights the importance of analyzing structural shifts within economic systems resulting
Vladimir N. Myakshin +3 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
MANAGING HOUSEHOLD FINANCIAL SECURITY IN THE RUSSIAN ARCTIC
Север и рынок: формирование экономического порядкаHousehold financial security management is a key factor in ensuring the socio-economic sustainability of the Russian Arctic regions, which are characterized not only by their strategic importance and resource potential but also by increased vulnerability
Anastasia N. Chapargina
doaj +1 more source
The second year of pandemic in the Arctic: examining spatiotemporal dynamics of the COVID-19 "Delta wave" in Arctic regions in 2021. [PDF]
Int J Circumpolar Health, 2022 Tiwari S +7 more
europepmc +1 more source