Results 61 to 70 of about 2,560,874 (291)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Agreement on Cooperation on Aeronautical and Maritime Search and Rescue in the Arctic [PDF]

, 2011
Agreement on Cooperation on Aeronautical and Maritime Search and Rescue in the Arctic - The SAR Agreement is the first legally binding agreement established under the auspices of the Arctic Council.
Arctic Council, -
core   +1 more source

Basic Income as a Measure of Social Support in the Arctic Regions of the Russian Federation: Statement of the Problem

Арктика и Север
The Arctic zone of the Russian Federation is one of the most promising resource and logistics regions of the state. A significant challenge to its development is the low population density, which hinders the development of necessary infrastructure and ...
Denis A. Novikov
doaj   +1 more source

95 years of climate and cryosphere studies of the Arctic in the Arctic and Antarctic Research Institute

Лëд и снег, 2015
A brief description of studies of the atmosphere, ocean, sea ice, and glaciers in the Arctic Regions and on the islands fulfilled since 1920 by scientists and specialists of the Arctic and Antarctic Research Institute (AARI) is presented.
G. V. Alekseev, D. Yu. Bolshiyanov, V. F. Radionov, S. V. Frolov   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Assessment of Transport Infrastructure Provision in the Russian Arctic Zone

Арктика и Север
The significant heterogeneity in the development of Russian regions in many parameters (population density, standard of living, provision of infrastructure) is most clearly evident in the Arctic territories.
Anastasia V. Vasilieva , Ksenija E. Sedova , Alina A. Larina   +2 more
doaj   +1 more source

THE ECOLOGICAL PROBLEMS OF THE RUSSIAN FEDERATION ARCTIC

Известия высших учебных заведений: Нефть и газ, 2015
The results of ecological researches in the Arctic zone of the Russian Federation (Purovski district of Yamal-Nenets Autonomous okrug) are presented.
N. L. Mamaeva, S. A. Petrov
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

The Inuvik Declaration, 1996. Declaration from the Ministerial meeting of the Arctic Environmental Protection Strategy (AEPS)held in Inuvik, Canada. [PDF]

, 1996
The Inuvik Declaration, March 21,1996. Declaration from the Ministerial meeting of the Arctic Environmental Protection Strategy (AEPS)held in Inuvik, Canada.
Arctic Council, -
core   +1 more source