Results 61 to 70 of about 32,527 (263)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

THE RADIO WAVES PROPAGATION CHARACTERISTICS IN THE GLIDESLOPE AXES OF THE GROUND CONTROLLED APPROACH SYSTEMS IN THE ARCTIC REGIONS

Научный вестник МГТУ ГА, 2016
Information about the location of the aircraft, with a decrease along a predetermined path, the carriages, the floor-fer with the use of radio landing systems.
G. S. Nakhmanson, D. V. Buchnev, A. V. Bunin   +2 more
doaj  

Implementation and Effectiveness of Antiretroviral Therapy in Greenland

Emerging Infectious Diseases, 2008
Analyses from the Danish HIV Cohort Study showed that, despite comparable economic means and general education of healthcare personnel, antiretroviral treatment of HIV in Greenland began later and has been implemented at a slower pace with lower ...
Nicolai Lohse, Karin Ladefoged, Niels Obel   +2 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Directions and Priorities for Tourism Development in the Arctic: Content Analysis of Strategic Documents

Арктика и Север
The number of strategic documents has been adopted at the federal level in recent years, establishing the regulatory regime for the development of tourism in the Arctic.
Svetlana V. Kondrateva , Ekaterina A. Shlapeko   +1 more
doaj   +1 more source

The second year of pandemic in the Arctic: examining spatiotemporal dynamics of the COVID-19 "Delta wave" in Arctic regions in 2021. [PDF]

Int J Circumpolar Health, 2022
Tiwari S, Petrov AN, Devlin M, Welford M, Golosov N, DeGroote J, Degai T, Ksenofontov S.   +7 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

DIGITALIZATION AS A TOOL FOR MANAGING INNOVATION-DRIVEN SUSTAINABLE DEVELOPMENT IN THE ARCTIC INDUSTRIAL SECTOR

Север и рынок: формирование экономического порядка
The sustainable development of industrial production is particularly critical in the Arctic regions. However, achieving this goal requires effective management, which can be improved through digitalization based on algorithmic processes.
Vladimir S. Zharov
doaj   +1 more source

Seasonal variations in physical activity among Norwegian elementary school children in Arctic regions. [PDF]

Int J Circumpolar Health, 2021
Danielsen KH, Vårnes TK, Sagelv EH, Heitmann KA, Mathisen GE.   +4 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source