Results 121 to 130 of about 3,061,171 (419)
Molecular Oncology, EarlyView.TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair +17 more
wiley +1 more source
Implementation and Effectiveness of Antiretroviral Therapy in Greenland
Emerging Infectious Diseases, 2008 Analyses from the Danish HIV Cohort Study showed that, despite comparable economic means and general education of healthcare personnel, antiretroviral treatment of HIV in Greenland began later and has been implemented at a slower pace with lower ...
Nicolai Lohse +2 more
doaj +1 more source
Elementa, 2019 As sources of reactive halogens, snowpacks in sea ice regions control the oxidative capacity of the Arctic atmosphere. However, measurements of snowpack halide concentrations remain sparse, particularly in the high Arctic, limiting our understanding of ...
P. Peterson +9 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
Арктика и СеверThe number of strategic documents has been adopted at the federal level in recent years, establishing the regulatory regime for the development of tourism in the Arctic.
Svetlana V. Kondrateva +1 more
doaj +1 more source
An analysis of potential conflict zones in the arctic region [PDF]
arXiv, 2016 As a result of the climate change the situation in Arctic area leads to several important consequences. On the one hand, oil and gas resources can be exploited much easier than before. Thus, one can already observe discussions on disputed shelf zones where the deposits are located.
arxiv
Directed-loop Monte Carlo simulations of vertex models
, 2004 We show how the directed-loop Monte Carlo algorithm can be applied to study vertex models. The algorithm is employed to calculate the arrow polarization in the six-vertex model with the domain wall boundary conditions (DWBC). The model exhibits spatially
D. Zeilberger +4 more
core +1 more source
Blue Bioeconomy in the Arctic region
, 2021 The blue bioeconomy is important to many Arctic communities, providing food and other valuable bioresources, generating value and employment, and supporting rural regions. This report looks at the Arctic blue bioeconomy by analyzing regional challenges, opportunities, best practices and success stories from Iceland, Norway and Northern Canada.
Bjornsdottir, Bryndis +9 more
openaire +2 more sources
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source
Effects of Arctic geoengineering on precipitation in the tropical monsoon regions
Climate Dynamics, 2018 Arctic geoengineering wherein sunlight absorption is reduced only in the Arctic has been suggested as a remedial measure to counteract the on-going rapid climate change in the Arctic.
Aditya Nalam, G. Bala, A. Modak
semanticscholar +1 more source