Lipid Nanoparticle Co‐Delivery of mRNA and a Small Molecule Drug for Oral Cancer Chemoimmunotherapy
Co‐encapsulation of p53 mRNA and the small molecule ciclopirox within a lipid nanoparticle yields an all‐in‐one chemoimmunotherapy for oral squamous cell carcinoma. The platform engages caspase‐driven apoptosis in cancer cells while repolarizing tumor‐associated macrophages, achieving tumor reduction in both p53‐susceptible and p53‐resistant models and
Marshall S. Padilla +15 more
wiley +1 more source
Quantifying Arctic-boreal methane emissions using atmospheric observations and a global inverse model. [PDF]
Basso LS +5 more
europepmc +1 more source
E. coli Extracellular Matrix: A Tunable Composite With Hierarchical Structure
The complex composite‐like mechanical behavior of E. coli biofilm matrix is the result of a synergic contribution of the rigid curli and swelling pEtN‐cellulose, and emerges from specific ratio and assembly conditions. The interactions between the two fibers govern biofilm hydration and characteristic wrinkling patterns, providing crucial insights for ...
Macarena Siri +7 more
wiley +1 more source
Population Genomic Structure and Demographic History of Black Guillemots Breeding Across the North Atlantic. [PDF]
Harkness BAS +5 more
europepmc +1 more source
A hierarchical hydrogel evaporator with a thin, porous photothermal layer of fused core–shell carbon‐polymer nanospheres enables ultrafast interfacial solar evaporation with minimized heat loss and sufficient water supply. Directional advection‐dominated brine transport, coupled with Marangoni‐driven interfacial flow, drives salt away from the active ...
Haokun Shen +11 more
wiley +1 more source
Rapid increase in West Siberia's retrogressive thaw slumps since 1964 associated with Arctic winter warming. [PDF]
Nesterova N +10 more
europepmc +1 more source
Evolution‐Driven Bio‐Composite Aerogels for Self‐Adaptive Thermal Regulation and Energy Storage
Inspired by nature's multiphase integration, a single chitosan (CTS)–metal chloride (MCl3) coordination precursor is engineered to enable sequential material and functional evolution. The resulting metal ion‐coordinated chitosan (CTS–M) aerogels exhibit humidity‐adaptive thermal insulation for battery safety, while carbonization yields conductive ...
Xiaoxue Zhang +5 more
wiley +1 more source
Pan-Arctic Peatlands Have Expanded During Recent Warming. [PDF]
Handley J +21 more
europepmc +1 more source
We report a wearable photonic patch integrating room light‐ and sunlight‐activatable luminescent particles (RSLPs) for both photochemical tissue bonding and photobiomodulation. RSLPs harvest ambient light and emit red luminescence to drive chlorin e6–mediated collagen crosslinking.
Kyungjoo Jo +12 more
wiley +1 more source
Climate-driven dust intensification over the Mongolian Gobi in early spring. [PDF]
Oh SS, Bai H, Lee HJ, Jo HY, Kim CH.
europepmc +1 more source

