Results 181 to 190 of about 162,083 (309)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Role of Atlantic multidecadal variability in modulating Arctic sea ice loss and wetting. [PDF]

Sci Adv
Cai Z, You Q, Screen JA, Chen HW, Zhang R, Zuo Z, Chen D, Cohen J, Kang S, Ma W, Gulev SK, Moore GWK, Zhang R.   +12 more
europepmc   +1 more source

Enhanced simulated early 21st century Arctic sea ice loss due to CMIP6 biomass burning emissions. [PDF]

Sci Adv, 2022
DeRepentigny P, Jahn A, Holland MM, Kay JE, Fasullo J, Lamarque JF, Tilmes S, Hannay C, Mills MJ, Bailey DA, Barrett AP.   +10 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Pan-Arctic sea ice drift data at 400 m grids based on spaceborne SAR. [PDF]

Sci Data
Qiu Y, Li XM.
europepmc   +1 more source

Influence of the recent winter Arctic sea ice loss in short-term simulations of a regional atmospheric model. [PDF]

Sci Rep, 2022
Cho H, Kug JS, Jun SY.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Arctic Sea Ice Melting Controls Sea Spray Aerosol Production. [PDF]

Environ Sci Technol
Dall'Osto M, Park J, Lee Y, Jung J, Kim JH, Yang EJ, Beddows DCS, Harrison RM, Sellegri K, Skov H, Massling A, Yoon YJ.   +11 more
europepmc   +1 more source

Robust but weak winter atmospheric circulation response to future Arctic sea ice loss. [PDF]

Nat Commun, 2022
Smith DM, Eade R, Andrews MB, Ayres H, Clark A, Chripko S, Deser C, Dunstone NJ, García-Serrano J, Gastineau G, Graff LS, Hardiman SC, He B, Hermanson L, Jung T, Knight J, Levine X, Magnusdottir G, Manzini E, Matei D, Mori M, Msadek R, Ortega P, Peings Y, Scaife AA, Screen JA, Seabrook M, Semmler T, Sigmond M, Streffing J, Sun L, Walsh A.   +31 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source